Milwaukee Regional Research Forum, Inc.

Milwaukee Regional Research Forum, Inc.

The Milwaukee Regional Research Forum, Inc. (MRRF) is a citizens inspired organization dedicated to advancing the goals of the Clinical and Translational Science Institute of southeast Wisconsin (CTSI). It was created to also inform our community about the CTSI and to communicate the collaborative research activity taking place involving CTSI’s eight partnering institutions: The Medical College of Wisconsin, Marquette University, University of Wisconsin – Milwaukee, Milwaukee School of Engineering, Children’s Hospital of Wisconsin, Froedtert Hospital, the Blood Center of Wisconsin, and Zablocki VA Medical Center. The MRRF is committed to identifying and promoting community awareness opportunities of the collaborative research activities between CTSI members.

The MRRF is also supported by the Public Policy Forum (PPF) – a Wisconsin-based, non-partisan think tank whose mission is to “seek, discover and disclose true and accurate information to enhance the effectiveness of government and public policy in southeastern Wisconsin, the state and the nation; and… facilitate public policy discussion and action”. The PPF devotes one of its annual meetings to feature the CTSI and CTSI-sponsored research.

History

Charles MulcahyThe Milwaukee Regional Research Forum, Inc. was created through the combined vision of two individuals, Dr. Reza Shaker and Charles C. Mulcahy.

Mr. Mulcahy, a retired attorney, is a former member of the Milwaukee County Board of Supervisors and MCW Trustee. Currently he is a member of the MCW Technology Innovation Council and a co-founder of the Milwaukee Regional Medical Center medical history wall project located in the Crowne Plaza Milwaukee West Hotel. Mr. Mulcahy continues to be a fervent supporter of the Milwaukee Regional Medical Center institutions and their important contribution to improving patient care, supporting scientific research, and regional economic development.

Charles Mulcahy
President
Milwaukee Regional Research Forum, Inc.
(414)254-6333 | Email

Objectives
  • Encourage research and technology transfer collaboration.
  • Provide outreach for CTSI to interact with community and business leaders.
  • With CTSI, interact with the business community on a mutually beneficial basis to develop timely and valuable research outcomes to improve patient care.
  • Present the T. Michael Bolger Award annually in recognition of exceptional accomplishments in biomedical research resulting in improved patient care and/or treatment and curing of disease.
  • Provide added resources for the development of intellectual property protection and the commercialization of research.
  • In collaboration with the Crowne Plaza Milwaukee West Hotel and Marquette University, develop a history wall in the Crowne Plaza Milwaukee West Hotel depicting the origin and evolution of the Milwaukee Regional Medical Center and CTSI.

T. Michael Bolger Award

T. Michael Bolger served with distinction and significant accomplishment as the president of the Medical College of Wisconsin from 1990 to 2010. During that period of time, the MCW experienced an extraordinary period of growth in faculty, operating revenues and budget, new facilities, new doctoral and masters programs and joint programs with CTSI entities.

T. Michael Bolger Award

T. Michael Bolger encouraged and supported MCW faculty to expand funded research and the successful creation and funding of the Clinical and Translational Science Institute funded through the National Institutes of Health.

The Bolger Award, in addition to recognizing and preserving the historic accomplishments of Mr. Bolger, also recognizes international, national or regional individuals or organizations whose accomplishments have resulted in improved patient care and/or the treatment and curing of disease.

2012 T. Michael Bolger Award Recipients
James S. Hyde, PhD

James S. Hyde, PhD

James S. Hyde, PhD

The James S. Hyde Professor of Biophysics
Director, National Biomedical EPR Center
Department of Biophysics
Medical College of Wisconsin

Since 1975, Dr. James S. Hyde has served with distinction on the faculty of the Medical College of Wisconsin. He is the James S. Hyde Professor of Biophysics and Director of the National Biomedical Electron Paramagnetic Resonance (EPR) Center.

After receiving his PhD in Physics from the Massachusetts Institute of Technology, Dr. Hyde spent 16 years in the private sector pursuing EPR research and development efforts. What is EPR? EPR is a process used in various branches of science for the detection and identification of free radicals. Dr. Hyde’s personal interest in EPR is contributing to the development of EPR instrumentation and to extend the ways in
which existing EPR instrumentation can be used for new categories of biomedical problems.

Since establishing the National Biomedical Electron Paramagnetic Resonance Center at the Medical College of Wisconsin, Dr. Hyde’s research excellence has resulted in continuous grant funding by the National Institutes of Health and the National Institute of Biomedical Imaging and Bioengineering.

Dr. Hyde has also pursed research interests in the area of functional magnetic resonance imaging (fMRI). His research has resulted in studies that seek to develop new ways to deal with the problem of motion in fMRI scans which can be severe in individuals who are ill or elderly. Dr. Hyde led the Medical College’s interdisciplinary team that was among the first in the world to develop fMRI of the working brain and his accomplishments in fMRI and EPR research have continued to influence the fields of radiology, neurology, ophthalmology and gastroenterology.

Milwaukee Journal Sentinel

Journal Sentinel ImageThe Milwaukee Journal Sentinel, with its predecessor entities, has provided comprehensive newspaper coverage to Milwaukee and Wisconsin markets since 1882.

The Milwaukee Journal and Milwaukee Sentinel were engaged and covered the creation and development of the Milwaukee Regional Medical Center starting in the 1970s. Over the intervening 40 years, the Milwaukee Journal Sentinel provided news coverage concerning the formation of the MRMC, the planning and development of the Medical College of Wisconsin, Froedtert Hospital, Blood Center of Wisconsin, Curative and Children’s Hospital.

MJS coverage has made the public aware of patient care and treatment as well as medical research and the commercialization of that research for improved patient care as well as licensing and new business formation. The coverage of public officials and private institutions throughout this development process was positive when warranted and critical when deserved.

MJS has also been courageous and diligent in raising public awareness of the shortcomings in treatment of the mentally ill and the care provided in nursing homes as well as with care providers. This coverage resulted in improvement in the care provided in private facilities and caused local and state government to more carefully fulfill their protective responsibilities.

MJS journalists during the past several years have received consistent and notable public recognition including the Pulitzer Prize, Bartlett & Stelle Award, Gerald Loeb Award, American Society of Newspapers Award, Eugene Pulliam Award, American Bar Association’s Silver Gavel Award, Polk Award, Grantham Award, and awards from the National Academy of Sciences, Institute of Medicine and National Academy of Engineering.

MJS has also provided unique, valuable and respected insight on the importance of medical research, patient care and economic development.

2011 T. Michael Bolger Award Recipients
Robert Wild, S.J.

Robert Wild, S.J.

Robert Wild, S.J.

Retired President
Marquette University

Father Wild served with distinction from 1996 to 2011 as President of Marquette University. Father Wild is recognized with this award for his leadership in guiding the University through dramatic changes in its growth and commitment to academic achievement, scholarly research, campus expansion and community involvement.

As a native of Chicago, Fr. Wild holds a doctoral degree from Harvard University, master’s and bachelor’s degrees from Loyola of Chicago and
a licentiate in theology from the Jesuit School of Theology in Chicago. He served as a faculty member at Marquette from 1975 to 1984.

Father Wild raised the national profile of Marquette in multiple areas but his legacy also includes improving Marquette’s health related programs in the School of Dentistry, College of Health Sciences and College of Nursing. These programs have achieved national recognition in research and education while developing a powerful workforce dedicated to improving the health of the people of Milwaukee, Wisconsin and the entire nation.

During his time as President, Marquette became a valuable and trusted member of the Clinical and Translational Science Institute and continued to expand its collaborations with CTSI entities.

Howard Jacob, PhD

Howard Jacob, PhD

Howard Jacob, PhD

Professor, Physiology and Human and Molecular Genetics
Director, Human and Molecular Genetics Center
Warren Knowles Chair in Genetics
Medical College of Wisconsin

Since 1996, Dr. Howard J. Jacob has served with distinction on the faculty of the Medical College of Wisconsin. Dr. Jacob is Professor of Physiology and Pediatrics; and Director of the Human and Molecular Genetics Center of MCW. He is the Warren P. Knowles Chair of Genetics at MCW.

Dr. Jacob received the PhD in Pharmacology at the University of Iowa and undertook postdoctoral training at Harvard and MIT. He was mentored, and later guided, by internationally recognized experts in pharmacology, cardiovascular physiology and genetics.

Dr. Jacob is recognized with this award for his extensive work in improving the health of patients and, for more than a decade, leading the development of the Human and Molecular Genetics Center into an internationally recognized research program geared to developing strategies to improve health. Taking advantage of comparative genomics between human, rat and mouse, Dr. Jacob has significantly advanced the understanding of the genetic determinants of renal disease and heart disease in humans.

Dr. Jacob has also experienced success in utilizing his research in developing technology transfer applications in various business settings intended to achieve positive health improvement results and resulting economic development. Last but not least, Dr. Jacob was instrumental in the development of the grant proposal that ultimately resulted in the federally funded CTSI of Southeast Wisconsin.

2010 T. Michael Bolger Award Recipient
T. Michael Bolger

T. Michael Bolger

T. Michael Bolger

President Emeritus
Medical College of Wisconsin

T. Michael Bolger served with distinction and significant accomplishment as the president of the Medical College of Wisconsin from 1990 to 2010. During that period of time, the MCW experienced an extraordinary period of growth including increase for faculty from 400 to 1,100; operating budget increased by 600% to over $850 million; $200 million of new facilities including the college’s Translational and Biomedical Research Center, Health Research Center and Cardiovascular Center/Anesthesiology research labs; three new doctoral programs; four new masters programs; joint programs with Marquette University and the Milwaukee School of Engineering; and expanded affiliation with Froedtert Hospital, Children’s Hospital of Wisconsin, BloodCenter of Wisconsin and Zablocki VA Medical Center.

Bolger achieved these changes and advancements in academic medicine with careful selection of talented people and a management style which created and maintained a positive and achievement oriented atmosphere.

Bolger encouraged and supported MCW faculty to expand funded research of $20 million in 1990 to over $145 million in 2010. The research initiative also included the successful creation and funding of the Clinical and Translational Science Institute which received a $20 million grant from the National Institutes of Health in 2010.

Public Policy Forum Viewpoint Luncheon

The nonpartisan Public Policy Forum, established in 1913 as a good government watchdog, currently focuses its policy research on a broad range of issues affecting southeastern Wisconsin, the state and the nation. This research includes government finance and economic development policy, education, transportation, public safety, health, public infrastructure and other quality of life concerns.

Public Policy Forum Luncheon

The Forum serves the public, businesses, government and other interested constituencies by spotlighting trends, defining emerging issues and facilitating productive interaction among local governments and the private sector to promote sound and innovative policy solutions.

Fiercely independent and widely respected for its unbiased research, the Forum is a source of accurate information for local, state and national leaders seeking effective answers to public policy issues.

In addition to publishing annual research reports, Research Briefs, and Regional Reports, the Forum hosts discussions and programs on issues of local and regional interest.

2014 Viewpoint Luncheon

2014 Annual Public Policy Forum Viewpoint Luncheon: Milwaukee County’s Future at the County Grounds

October 27, 2014

Purchased by Milwaukee County in 1852 and exclusively occupied for a century by County institutions, the Milwaukee County Grounds in Wauwatosa now house one of the state’s foremost clusters of private health care institutions and businesses. Meanwhile, the County’s Mental Health Complex will soon shrink to fewer than 80 beds and its overall presence on the Grounds is vastly diminished.

  • Should Milwaukee County continue to own and occupy space on the County Grounds, or is it time for a new ownership structure?
  • Who should provide water and stormwater services, and who should pay for fire and police?
  • What are the prospects for a cooperative discussion between Wauwatosa, the County, and private sector leaders to resolve these issues?

Join the Public Policy Forum at a Viewpoint Luncheon that will explore Milwaukee County’s future at the County Grounds.

Panel

Our panel of government and private sector leaders includes:

  • Chris Abele, Milwaukee County Executive
  • Kathy Ehley, Wauwatosa Mayor
  • Guy Mascari, Director of Development, Milwaukee County Research Park
  • Dr. John Raymond, President and CEO, Medical College of Wisconsin

Moderated by

Rob Henken, President, Public Policy Forum

Welcoming remarks

Marquette University President, Michael Lovell, on collaboration at the UWM Innovation Campus

2012 Viewpoint Luncheon

2012 Viewpoint Luncheon
Milwaukee’s Information Technology Infrastructure:
Do We Have What It Takes to Compete?

Greater Milwaukee’s economic development leaders are working on several initiatives to enhance the region’s competitiveness, including high-profile efforts to promote water and energy clusters, enhance academic research and nurture entrepreneurs.

Some are asking, however, whether we possess the high-performance computing infrastructure needed to achieve those and other economic development goals. How does our region measure up when it comes to IT infrastructure and why does it matter?

Who are the key players and who would supply the resources to expand our capacity? Overall, what will it take to build the IT infrastructure needed to compete for research dollars and knowledge workers in a 21st century global economy?

This Public Policy Forum Viewpoint Luncheon will explore Milwaukee’s information technology prowess and its importance to our regional economy.

PANEL DISCUSSION

Dr. Jay Bayne, Executive Director, Milwaukee Institute
David Crass, Director of Research Cyberinfrastructure, UW-Milwaukee
Tina M. Chang, Chief Executive Officer, SysLogic, Inc.
Nancy Olson, Chief Information Officer, City of Milwaukee

MODERATED BY

Kathleen Gallagher, Milwaukee Journal Sentinel

2011 Viewpoint Luncheon

2011 Viewpoint Luncheon

The Role of our Colleges and Universities in Building Milwaukee’s Future

Greater Milwaukee is home to several colleges and universities, including four that collectively spend more than $200 million annually on research and development. How are those institutions transferring new discoveries to the commercial sector for public benefit? Would enhanced collaboration among the four produce greater dividends for our regional economy? What is the appropriate role of our colleges and universities in fostering economic growth and tackling the difficult issues facing our region?

This Public Policy Forum Viewpoint Luncheon discussed how our colleges and universities view their role in addressing Greater Milwaukee’s economic and social challenges.

PANEL DISCUSSION

John R. Raymond, MD, President & CEO, Medical College of Wisconsin
Hermann Viets, PhD, President, Milwaukee School of Engineering
Jeanne M. Hossenlopp, PhD, Vice Provost for Research and Dean of the Graduate School, Marquette University
Brian D. Thompson, President, University of Wisconsin – Milwaukee Research Foundation

MODERATED BY

Rob Henken President, Public Policy Forum

5 MBDownload the 2011 MRRF Program Booklet
2010 Viewpoint Luncheon

2010 Viewpoint Luncheon

Reaping the Benefits of Academic Research

A new $20 million federal research grant awarded to Milwaukee-area research institutions to establish the Clinical and Translational Science Institute has generated new hope regarding our region’s research prowess. Now, many are asking whether the momentum can be sustained. What will it take to attract more federal research dollars to metro Milwaukee? What is the role of state and local government in promoting university research and encouraging economic spin-off? Can we build the high-tech infrastructure needed to successfully compete for research dollars and effectively reap the benefits of academic research?

PANEL DISCUSSION

Dr. Jay Bayne, Executive Director, The Milwaukee Institute
Dr. Marc Levine, Professor, UWM Center for Economic Development
Daniel Steininger, Co-Founder, BizStarts Milwaukee
Tom Still, President, Wisconsin Technology Council

MODERATED BY

Dr. Stephen L. Percy, Acting Dean, UWM School of Public Health and Director, UWM Center for Urban Initiatives and Research

5 MBDownload the 2010 MRRF Program Booklet

CTSI Sponsored Research Poster Sessions

Poster Sessions

The poster sessions showcase research projects supported by CTSI as well as how these projects demonstrate collaborative efforts across disciplines and institutions.

CTSI Sponsored Research
2012 Poster Session

The following posters were on display at the 2012 Milwaukee Regional Research Forum:

Preclinical Study to Optimize Anti-tumor Immune Activation Against Multiple Myeloma using Tumor Vaccination in Combination with Lymphodepletion and Immune Modulating Agents

Objective: To find a combination of immune therapies that facilitate the identification of tumor cells as well as a robust activation of killer immune cells that result in unbounded tumor regression.
Investigators: Tyce Kearl, Jill Gershan, William Drobyski and Bryon Johnson

Nurses’ Perceptions of Communication Skills for Parenting an Infant with a Congenital Heart Defect

Objective: To design interventions to improve communication skills and specifically addressing challenges parents face in working with substitute care providers that could improve care.
Investigators: Mussatto K, Henriques J, Krolikowski M, Brosig Soto C, Melby J, Harrison T, Pridham K.

Collagen Binding Provides a Sensitive Screen for Variant Von Willebrand Disease

Objective: A comparison of VWF collagen binding (VWF:CB) and VWF multimer distribution was performed to evaluate the utility of VWF:CB as a diagnostic test.
Investigators: Veronica H. Flood, Joan Cox Gill, Kenneth D. Friedman, Pamela A. Christopherson, Paula M. Jacobi, Raymond G. Hoffmann, Robert R. Montgomery, and Sandra L. Haberichter

Alterations of Intestinal and Tissue-nonspecfic Alkaline Phosphatase Activity in a Neonatal Rat Model of Necrotizing Enterocolitis

Objective: To determine which AP isoforms are prevalent in healthy and NEC neonates.
Investigators: Ben E. Biesterveld, Rebecca M. Rentea, Scott R. Welak, Diana G. Lerner, Katherine M. Fredrich, David M. Gourlay

Stochastic Resonance Improves Sensation in Chronic Stroke Survivors

Objective: To determine if vibro-tactile stimulation using stochastic resonance can enhance stroke survivors’ tactile sensation at the fingertips.
Investigators: Leah R. Enders, Na Jin Seo

Intracortical inhibition for grip relaxation in chronic stroke survivors

Objective: To determine the role of the modulation of the intracortical inhibition (quantified as short-interval intracortical inhibition, SICI, using transcranial magnetic stimulation) in abnormally delayed grip relaxation after stroke.
Investigators: Binal Motawar, Na Jin Seo

Computational Methods for Patient-Specific modeling of Transcranial Magnetic Stimulation

Objective: To quantify the degree, type, and location of neural modulation during TMS to provide foundational information necessary to target, or avoid targeting, specific anatomical regions in the brain.
Investigators: Brian D. Goodwin, Manoj Raghavan, Klaus Driesslein, Christopher R. Butson

Optimizing an Assistive Glove for Stroke Survivors using Biomechanical Model

Objective: To optimize the current glove design using a biomechanical model that results in natural hand opening for stroke survivors.
Investigators: Pilwon Hur, Daniel Lomo-Tettey, Na Jin Seo

Toll-like receptor genetic variants alter susceptibility to Gram-negative sepsis in premature infants

Objective: To determine whether a) single nucleotide polymorphisms (SNPs) in the TLR genes modulate susceptibility to sepsis in VLBW infants, and b) TLR SNPs modulate WBC counts obtained during culture-positive (C+ve) sepsis.
Investigators: Venkatesh Sampath, Neil P. Mulrooney, Jeffery S. Garland, Jie Ye, Aloka L. Patel, Jonathan D. Cohen, Pippa M. Simpson, Ronald N. Hines

Development of a Mobile Computing Framework for Effective Self-Management of Type II Diabetes

Objective: To present a Common Sense Model (CSM) that sets the patient’s “model” of diabetes in a mobile computing framework where behaviors are easily and logically linked to disease outcomes through continuous monitoring of SMBG, heart rate, medications, diet, and exercise.
Investigators: Jay Urbain, Edith Burns, Paul Knudson, Megan Fedders, Bambi Wessel, William Klitzkie, Ann Swartz, Scott Strath

IL-27 initiates strong, early NK cell-mediated effector functions in a murine model

Objective: To understand the role of IL-27 in natural killer (NK) cell-based effector functions.
Investigators: Monica S. Thakar, Pawan Kumar, Kamalakannan Rajasekaran, Kristina Schuldt, Subramaniam Malarkannan

Proteomics of Glioblastoma Multiforme – Moving Towards Personalized Medicine

Objective: To identify protein signatures that are unique to each GBM patient; determine if they predict a differential response to Bevacizumab therapy and provide unique information for the development of new drug targets either in combination or as an alternative to Bevacizumab therapy.
Investigators: Maxime Heroux, Marla Chesnik, Mona Al Gizawiy, Elizabeth Cochran, Scott Rand, Jennifer Connelly, Wade Mueller, Mark Malkin, Kathleen Schmainda and Shama Mirza

CXCR4-Expressing Mesenchymal Stem Cells for TBI

Objective: To determine the role of stromal cell-derived factor 1 (SDF-1) and its cognate receptor chemokine receptor 4 (CXCR4) in the migration and rejuvenating effect of BMSC transplanted in an in vitro model of TBI.
Investigators: Aleksandra Glavaski-Joksimovic and Milan Joksimovic

Radiation-Induced Changes in Intestinal and Tissue Nonspecific Alkaline Phosphatase: Implications for Recovery of Radiation Chemotherapy

Objective: To determine if radiation-induced intestinal radiation injury would be mitigated by oral IAP supplementation in an adult rat model.
Investigators: Rebecca M. Rentea, Vy Lam, Katherine Fredrich, Jennifer Callison, John E. Moulder, John E. Baker, David M Gourlay, Mary F. Otterson

A Novel Brain Target for the Treatment of Schizophrenia

Objective: To identify therapeutic agents that would be effective in treatment of the negative and cognitive symptoms of schizophrenia.
Investigators: Dana A. Ley, Joseph McGraw, Daniel Sem, Kambiz Pahlavan, Gunnar Larson, M. Behnam Ghasemzadeh

Novel Orally Active Epoxyeicosatrienoic Acid (EET) Analogs Attenuate Cisplatin Nephrotoxicity

Objective: To determine if EET analogs would decrease cisplatin-nephrotoxicity.
Investigators: Md. Abdul H. Khan, Jessica L. Meyer, Katherine A. Walsh, John R. Falck, Jawahar L. Jat, Vijay L. Manthati, John D. Imig

Nogo Protein Responses to Hyperoxia in the Developing Brain

Objective: To investigate the potential role of Nogo protein in CNS pathophysiology in the presence of hyperoxia. We hypothesize that Nogo proteins have a protective effect on neuronal and axonal development.
Investigators: Susan S. Cohen, Ru-Jeng Teng, Qing (Robert) Miao, G. Ganesh Konduri

Optical Imaging of Oxidative Stress in Lung from Hyperoxia and LPS in Neonatal Rats

Objective: To investigate whether an optical imaging technique to evaluate mitochondrial metabolic coenzymes, NADH and FAD will delineate oxidative stress from hyperoxia and LPS in neonatal rat lungs.
Investigators: Reyhaneh Sepehr, Annie L. Eis, Girija G. Konduri, Mahsa Ranji

Human Induced Pluripotent Stem Cells as a Novel Model System to Study Dystrophic Cardiomyopathy

Objective: To determine whether induced pluripotent stem cells (iPSCs) derived from BMD and DMD patients could be differentiated into cardiomyocytes and retain a specific disease phenotype.
Investigators: Jennifer L. Strande, Scott Canfield, Jennifer Meyer, Zeljko J. Bosnjak

Searching for Biomarkers in Heart Failure with Preserved Ejection Fraction

Objective:To identify a proteomic-based peripheral blood biomarker panels in a serial and prospective monitoring strategy in HFpEF patients.
Investigators:Shama Mirza, Marla Chesnik, Courtney Van Dusen, and Jennifer L. Strande

Impairments in Sensorimotor Control and their Contribution to Tremor & Dysmetria in Persons with MS

Objective: To characterize the functional sources of upper limb tremor and dysmetria that occur in patients with Multiple Sclerosis (MS) using a systems identification approach together with a closed-loop model of sensorimotor control.
Investigators: Megan Heenan, Douglas Woo, Robert Scheidt, Julie Bobholz, Scott Beardsley

Metabolic Oxidation Studies of Isolated Perfused Rat Lung Using Surface Fluorescence

Objective: To evaluate a device that measures the oxidation of tissue metabolism using optical fluorescence techniques.
Investigators: Kevin Staniszewski, Reyhaneh Sepehr , Mahsa Ranji, Said H. Audi, Elizabeth R. Jacobs

Varying Patterns of Home Oxygen Use at NICU Discharge Across Gestational Ages

Objective: To evaluate home oxygen use for pre-term infants with chronic lung disease.
Investigators: Joanne Lagatta, Reese Clark, David Brousseau, Raymond Hoffmann, Alan Spitzer

Ex Vivo Thermoacoustic Prostate Cancer Imaging

Objective: To determine if TCT can detect extracapsular extension of PCa.
Investigators: M Thomas, E Hanson, H Kelly, K Jacobsohn, W See, S Patch

Molecular analysis of blue light irradiated Methicillin Resistant Staphylococcus aureus (MRSA)

Objective: To examine blue light irradiated MRSA colonies at the molecular level by observing the effect of blue light on femA and mecA genes implicated in antibiotic resistance; analyzing the protein profile of whole cell lysates and genomic fingerprinting using Pulsed field gel electrophoresis (PFGE) and Diversilab repPCR.
Investigators: Bumah VV, Masson-Meyers DS, Bhattacharyya S, Khubbar M, Gradus S, Whelan H & Enwemeka CS

Dopaminergic-like neurons from epigenetically reprogrammed mesenchymal stem cells.

Objective: To elucidate whether NI-hMSCs can be differentiated into the dopaminergic (DA) neuronal subtype.
Investigators: Ryan Funk, Arshak R. Alexanian

2011 Poster Session

The following posters were on display at the 2011 Milwaukee Regional Research Forum:

Mechanisms of Sensorimotor Impairment in Multiple Sclerosis

Objective: To develop a better understanding of neuromuscular defects and hence improve function in patients with multiple sclerosis
Investigators: Chua, Matthew, PhD (MU), Hyngstrom, Allison, PT, PhD (MU), Ng, Alexander, PhD (MU), Woo, Douglas MD (MCW), Schmit, Brian D., PhD (MU)

Impairments in Sensorimotor Control And Their Contribution To Tremor & Dysmetria in Persons With MS

Objective: To develop a model, using a systems identification approach, to characterize the functional sources of upper limb tremor and dysmetria in patients with multiple sclerosis
Investigators: Beardsley, Scott, PhD (MU), Scheidt, Robert, PhD (MU), Woo, Douglas, MD (MCW) and Bobholz, Julie, PhD (MCW)

A Novel High-Resolution Reduced Field-Of-View Diffusion Tensor Imaging Method

Objective: To develop a sensitive and efficient non-invasive imaging method to identify the extent of surgically resectable lesions in patients with brain tumors
Investigators: Gaggl, Wolfgang, MSEE (MCW) and Prost, Robert W., PhD (MCW)

Mechanisms of Neuromuscular Fatigue and Leg Function Post Stroke

Objective: To examine the neural pathways responsible for “neuromuscular fatigue” and their relationship to ambulation in post-stroke patients
Investigators: Hyngstrom, Allison, PhD (MU), Keenan, Keith, PhD (UWM), Nelson, Philip A. MD (MCW), Hunter, Sandra, PhD (MU), and Schmit, Brian, PhD (MU)

Supraspinal Contributions to Upper and Lower Limb Motor Control and Recovery after Stroke – an fMRI Study

Objective: To enhance the understanding of how the brain controls movements in people with and without stroke, with the long term objective of providing a scientific rationale for the development of more effective interventions
Investigators: Schindler-Ivens, Sheila, PT, PhD (MU), Johnson, Michelle J. PhD (MCW), Kamara, Sheku (MSOE), Wang, Jinsung, PhD (UWM), Bao, Shancheng (MU)

Alterations of endocannabinoid signaling, synaptic plasticity, learning and memory in Monoacylglycerol lipase knockout mice

Objective: To evaluate a genetically regulated molecular mechanism affecting learning behavior and memory in a mouse model
Investigators: Pan, Bin, MD (MCW), Wang,Wei (MCW), Zhong, Peng (MCW), Blankman, Jacqueline L. (Scripps Research Institute), Cravatt, Benjamin F., PhD (Scripps Research Institute) and Liu, Qing-song, PhD (MCW)

Functional characterization of a region deleted in a patient with congenital glaucoma

Objective: To identify the genetic mechanism of congenital glaucoma in a patient with a novel genetic mutation
Investigators: Schilter, Kala F. (MCW), Reis, Linda M. (MCW) and Semina, Elena V., PhD (MCW)

Mapping the Effects of the KIAA0319 Dyslexia Susceptibility Gene on the Neural Substrates of Reading

Objective: To evaluate the neural and behavioral correlates of a specific genetic mutation that may be associated with dyslexia
Investigators: Conant, Lisa L., PhD (MCW), Graves, William W., PhD (MCW), Osmon, David C., PhD (UWM), Binder, Jeffrey R., MD (MCW)

A Novel Approach to the Identification of Candidate Genes in Patients with Lymphatic Malformations

Objective: To develop a novel model for isolating lymphatic endothelial cells from patients with lymphatic malformations to enable future identification of genes contributing to these malformations
Investigators: Duffy, Kelly, PhD (MCW), Johnson, Craig, DO (MCW), Samant, Ganesh, PhD (MCW), Santoro, Jennifer (MCW), Ramchandran, Ramani, PhD (MCW)

Phenothiazines as New Antibiotics

Objective: To evaluate the effectiveness of phenothiazines (anti-psychotic drugs) in a mouse model of infections caused by methicillin resistant staphylococcus aureus
Investigators: Sohnle, Peter G., MD, (MCW) and Hahn, Beth L. (MCW)

Receptor of Advanced Glycation End Products (RAGE) Expression and Activation in Endothelium Derived Microparticle (EMP)-Induced Acute Lung Injury

Objective: To develop specific therapeutic targets, based on the pathophysiology of lung injury, in patients with acute lung injury
Investigators: Jeziorczak, Paul M., MD (MCW), Kaul, Sushma, MSc, MS (MCW), Pritchard, Jr., Kirkwood A., PhD (MCW), Oldham, Keith T., MD (MCW), Jacobs, Elizabeth R., MD (MCW), and Densmore, John C., MD (CHW)

Noninvasive detection and assessment of two common lung injuries

Objective: To develop the use of single-photon emission computed tomography (SPECT) imaging agents as non-invasive biomarkers of cell death and changes in redox status in early lung disease/injury
Investigators: Clough, Ann V., PhD (MU), Audi, Said, PhD (MU), Roerig, David L., PhD (MCW), Haworth, Steven T., PhD (MCW) and Jacobs, Elizabeth R., MD (MCW)

In Vivo MicroRNA Profiling of Celecoxib Toxicity in Squamous Cell Carcinoma of the Head and Neck

Objective: To investigate the molecular mechanisms of the synergistic in-vivo toxicity of radiotherapy and celecoxib, a non-steroidal anti-inflammatory drug, as applied in the treatment of patients with squamous cell carcinoma of the head and neck, a very high-mortality cancer.
Investigators: Bock, Jonathan M., MD (MCW) and You, Ming, MD, PhD (MCW)

Psychosocial Factors and Hematopoietic Stem Cell Transplantation

Objective: To evaluate the relationship between psychosocial factors and clinical outcomes in bone marrow transplant recipients
Investigators: Knight, Jennifer M., MD (MCW), Moynihan, Jan A., PhD (University of Rochester), Lyness, Jeffrey M., MD (University of Rochester), Xia, Yinglin, PhD (University of Rochester), Tu, Xin, PhD (University of Rochester), Hunter, Bryan C. PhD, LCAT, MT-BC (Nazareth College), Huang, Li-Shan PhD (University of Rochester), Obi, Rosemary O. MS, LCAT, MT-BC (University of Rochester), Gaisser, D’Arcy MS, APRN, (University of Rochester), Liesveld, Jane L. MD (University of Rochester) , Sahler, Olle Jane Z., MD (University of Rochester)

Interstitial fibrosis in the renal inner medulla in humans is associated with up-regulation of miR-382 and down-regulation of kallikrein 5

Objective: To understand the genetic basis of one form of chronic renal injury (interstitial fibrosis) in the human kidney
Investigators: Kriegel, Alison, PhD (MCW), Mladinov, Domagoj (MCW), Kelly, Holly (MCW), Langenstroer, Peter, MD (MCW), See, William, MD (MCW), Liang, Mingyu, PhD (MCW)

Loss of Activator of G Protein Signaling 3 Impairs Renal Tubular Regeneration Following Acute Kidney Injury in Rodents

Objective: To study intracellular mechanisms underlying renal tubular epithelial cell proliferation and tubular repair following ischemia-reperfusion injury
Investigators: Regner, Kevin R., MD (MCW), Nozu, Kandai, PhD (MCW), Lainier, Stephen M., PhD (Medical University of SC, Charleston), Blumer, Joe B. PhD (Medical University of SC, Charleston), and Avner, Ellis D.MD (MCW)

Human Induced Pluripotent Stem Cells as a novel model to study dystrophic cardiomyopathy

Objective: To develop a human model of dystrophic cardiomyopathy in order to study the underlying mechanisms responsible for cardiomyocyte failure and to validate this model as a tool for drug discovery
Investigators: Strande, Jennifer L. MD, PhD (MCW) and Bosnjak, Zeljko J. PhD (MCW)

NT-proBNP as an Early Predictor of LV Dysfunction in Children Receiving Anthracycline Chemotherapy

Objective: To evaluate a hormonal marker that would predict the development of left ventricular dysfunction in children receiving anthracycline chemotherapy
Investigators: Gudausky, Todd M., MD (MCW) and Tower II, Richard L., MD, MS (MCW)

Obesity does not predict insulin resistance among African American women

Objective: To compare the associations of different gender-based adiposity distributions on cardiovascular disease risk factors in African American women and men
Investigators: Kidambi, Srividya, MD (MCW), Coly, Gerard, MD (MCW), Widlansky, Michael, MD (MCW)

Targeting of Epoxyeicosanoids for Renal and Cardiovascular Diseases

Objective: To determine if genetic manipulation of vascular epoxyeicosanoids (EETs) improves vascular function in insulin resistant and obese mice
Investigators: Walsh, Katherine M. (MCW), Imig, John D., PhD (MCW)

Mitochondrial Redox Studies by Optical Spectroscopy and CryoImaging in Pulmonary Oxidative Stress

Objective: Investigating Near Infra Red Spectroscopy (NIRS) for assessing tissue oxygenation in patients with acute respiratory distress syndrome following a life-threatening injury.
Investigators: Ranji, Mahsa, PhD (UWM), Jacobs, Elizabeth, MD (MCW), Audi, Said, PhD (MU)

Mitochondrial oxidative stress in lung injury from sepsis

Objective: Novel chemical probes and synthetic peptides are applied to investigate the role of reactive oxygen species produced in rat lungs as a result of infection and high oxygen concentration.
Investigators: Konduri, Girija Ganesh, MD (MCW), Jacobs, Elizabeth, MD (MCW), Pritchard, Jr., Kirkwood A., PhD (MCW), Ranji Mahsa, PhD (UWM), Audi, Said, PhD (MU)

CTSI Pilot Fuzzy Logic Application for T2DM

Objective: To develop a “smart phone” to assist diabetic patients with self-monitoring of blood glucose

Investigators: Urbain, Jay, PhD (MSOE), Burns, Edith, MD (MCW), Knudson, Paul, MD (MCW), Fedders, Megan, MS (MCW), Wessel, Bambi, MA (MCW), Strath, Scott, PhD (UWM), and Swartz, Ann, PhD (UWM)

Introducing Students to the Process of Science through Modeling

Objective: To introduce high school students to the process of science through the creation of physical models of proteins by rapid prototyping technology
Investigators: Colton, Shannon, PhD (MSOE), Franzen, Margaret, PhD (MSOE), Hoelzer, Mark (MSOE) and Herman, Tim, PhD (MSOE)

Developing CTSI-Second World and Testing its Efficacy

Objective: To investigate the efficacy of delivering healthcare services in the 3D virtual world called Second Life that simulates the real world in order to increase access to and reduce the cost of healthcare
Investigators: Zahedi, F.Mariam, DBA (UWM), Shaker, Reza, MD (MCW), Jain, Hemant, PhD (UWM), Walia, Nitin, PhD (UWM)

Developing a Combined Research and QI Database from Community Based Practices with Different IT Systems

Objective: To develop a centralized database to better understand the high prevalence of poor birth outcomes in southeastern Wisconsin
Investigators: Eldredge, Christina, MD (MCW), Slawson, James, MD (MCW), Granados, Rodolfo (MCW), Payne, Judy (MCW)

What Happens When a Nurse Pain Protocol is Discontinued in the Emergency Department?

Objective: To determine if discontinuation of a nurse protocol in the Emergency Department changes (1) the proportion of children receiving an analgesic and (2) the timeliness of analgesic administration
Investigators: Kelly, Brian T., MD (MCW), Friend, Tiama, MD (MCW) and Drendel, Amy L., DO, MS (MCW)

Health-Related Quality of Life in Pediatric Minor Injury: Reliability, validity, and responsiveness of the Pediatric Quality of Life Inventory in the emergency department

Objective: To evaluate the feasibility, reliability, validity, and responsiveness of the acute version of the Pediatric Quality of Life Inventory scales after Emergency Department care of minor injury
Investigators: Stevens, Martha W., MD (MCW), Hainsworth, Keri R., PhD (MCW), Weisman, Steven J, MD (MCW) and Layde, Peter M., MD, MPH (MCW)

Community Perspectives of a CTSI Website: A process for change and application

Objective: To improve the effectiveness of the internet as a vehicle for communication between community and academic partner
Investigators: Nelson, David, PhD, MS (MCW), Opel, Shannon, MPH (MCW), Kissack, Anne, MPH, RD (MCW), Granados, Ody, BA (MCW) and Ahmed, Syed, MD, MPH, Dr.PH (MCW)

Master of Science Program in Clinical & Translational Science

Objective: To showcase the new M.S. Program in Clinical & Translational Science that offers both education and application opportunities in two broad areas of emphasis, i.e., Translational Research, and Commercial Development of Drugs, Biologics, Devices, and Diagnostics
Authors: Kusch, Jennifer, PhD (MCW), Kotchen, Jane, MD, MPH (MCW), Hefti, Arthur, DDS, PhD (Marquette University), Chelius, Tom, MS (MCW), Erby, Chaunté (MCW)

NIH Funding Acknowledgment: Important Reminder – Please acknowledge the NIH when publishing papers, patents, projects, and presentations resulting from the use of CTSI resources by including the NIH Funding Acknowledgement.

PARTNERS
Zablocki VA Medical CenterFroedtert HospitalMedical College of Wisconsin Childrens Hospital of WisconsinBloodCenter of WisconsinUniversity of Wisconsin - MilwaukeeMarquette UniversityMilwaukee School of Engineering