The Milwaukee Regional Research Forum, Inc. (MRRF) is a citizen inspired organization dedicated to advancing the goals of the Clinical & Translational Science Institute of Southeast Wisconsin (CTSI). It was created to inform our community about the CTSI and to communicate the collaborative research activities taking place involving CTSI’s eight partnering institutions: The Medical College of Wisconsin, Marquette University, University of Wisconsin – Milwaukee, Milwaukee School of Engineering, Children’s Hospital of Wisconsin, Froedtert Hospital, the BloodCenter of Wisconsin, and Milwaukee VA Medical Center.
Title Sponsor for the Milwaukee Regional Research Forum is the Al Hurvis/ADAMM Education Foundation Inc. A 501(c)(3) tax-exempt, non-profit Wisconsin corporation created in 2015 when J. Thomas Hurvis and Charles C. Mulcahy joined forces with Jim Tolkan, president of the Automobile Dealers Association of Mega Milwaukee (ADAMM) to administer and provide scholarships for graduating high school seniors. Focusing on underrepresented minority students, the Foundation administers eight scholarships based on academic achievement, leadership, community service, and financial need.
The Milwaukee Regional Research Forum, Inc. was created through the combined vision of two individuals, Dr. Reza Shaker and Charles C. Mulcahy.
Mr. Mulcahy, a retired attorney, is a former member of the Milwaukee County Board of Supervisors and MCW Trustee. Currently he is a member of the MCW Technology Innovation Council and a co-founder of the Milwaukee Regional Medical Center medical history wall project located in the Crowne Plaza Milwaukee West Hotel. Mr. Mulcahy continues to be a fervent supporter of the Milwaukee Regional Medical Center institutions and their important contribution to improving patient care, supporting scientific research, and regional economic development.
Milwaukee Regional Research Forum, Inc.
(414)254-6333 | Email
T. Michael Bolger served with distinction and significant accomplishment as the President of the Medical College of Wisconsin (MCW) from 1990 to 2010. During his time as President, MCW experienced extraordinary growth in faculty, operating revenues and budget, new facilities, new Doctoral and Masters programs, and joint programs with CTSI entities.
T. Michael Bolger supported and encouraged faculty to expand funded research opportunities, including the successful creation of the Clinical and Translational Science Institute (CTSI), funded through the National Institutes of Health (NIH).
In honoring and preserving Mr. Bolger’s historic accomplishments, the T. Michael Bolger Award recognizes regional, national, or international individuals or organizations whose accomplishments resulted in improved patient care and/or treatment and cure of diseases.
The James S. Hyde Professor of Biophysics
Director, National Biomedical EPR Center
Department of Biophysics
Medical College of Wisconsin
Since 1975, Dr. James S. Hyde has served with distinction on the faculty of the Medical College of Wisconsin. He is the James S. Hyde Professor of Biophysics and Director of the National Biomedical Electron Paramagnetic Resonance (EPR) Center.
After receiving his PhD in Physics from the Massachusetts Institute of Technology, Dr. Hyde spent 16 years in the private sector pursuing EPR research and development efforts. What is EPR? EPR is a process used in various branches of science for the detection and identification of free radicals. Dr. Hyde’s personal interest in EPR is contributing to the development of EPR instrumentation and to extend the ways in
which existing EPR instrumentation can be used for new categories of biomedical problems.
Since establishing the National Biomedical Electron Paramagnetic Resonance Center at the Medical College of Wisconsin, Dr. Hyde’s research excellence has resulted in continuous grant funding by the National Institutes of Health and the National Institute of Biomedical Imaging and Bioengineering.
Dr. Hyde has also pursed research interests in the area of functional magnetic resonance imaging (fMRI). His research has resulted in studies that seek to develop new ways to deal with the problem of motion in fMRI scans which can be severe in individuals who are ill or elderly. Dr. Hyde led the Medical College’s interdisciplinary team that was among the first in the world to develop fMRI of the working brain and his accomplishments in fMRI and EPR research have continued to influence the fields of radiology, neurology, ophthalmology and gastroenterology.
The Milwaukee Journal Sentinel, with its predecessor entities, has provided comprehensive newspaper coverage to Milwaukee and Wisconsin markets since 1882.
The Milwaukee Journal and Milwaukee Sentinel were engaged and covered the creation and development of the Milwaukee Regional Medical Center starting in the 1970s. Over the intervening 40 years, the Milwaukee Journal Sentinel provided news coverage concerning the formation of the MRMC, the planning and development of the Medical College of Wisconsin, Froedtert Hospital, Blood Center of Wisconsin, Curative and Children’s Hospital.
MJS coverage has made the public aware of patient care and treatment as well as medical research and the commercialization of that research for improved patient care as well as licensing and new business formation. The coverage of public officials and private institutions throughout this development process was positive when warranted and critical when deserved.
MJS has also been courageous and diligent in raising public awareness of the shortcomings in treatment of the mentally ill and the care provided in nursing homes as well as with care providers. This coverage resulted in improvement in the care provided in private facilities and caused local and state government to more carefully fulfill their protective responsibilities.
MJS journalists during the past several years have received consistent and notable public recognition including the Pulitzer Prize, Bartlett & Stelle Award, Gerald Loeb Award, American Society of Newspapers Award, Eugene Pulliam Award, American Bar Association’s Silver Gavel Award, Polk Award, Grantham Award, and awards from the National Academy of Sciences, Institute of Medicine and National Academy of Engineering.
MJS has also provided unique, valuable and respected insight on the importance of medical research, patient care and economic development.
Father Wild served with distinction from 1996 to 2011 as President of Marquette University. Father Wild is recognized with this award for his leadership in guiding the University through dramatic changes in its growth and commitment to academic achievement, scholarly research, campus expansion and community involvement.
As a native of Chicago, Fr. Wild holds a doctoral degree from Harvard University, master’s and bachelor’s degrees from Loyola of Chicago and
a licentiate in theology from the Jesuit School of Theology in Chicago. He served as a faculty member at Marquette from 1975 to 1984.
Father Wild raised the national profile of Marquette in multiple areas but his legacy also includes improving Marquette’s health related programs in the School of Dentistry, College of Health Sciences and College of Nursing. These programs have achieved national recognition in research and education while developing a powerful workforce dedicated to improving the health of the people of Milwaukee, Wisconsin and the entire nation.
During his time as President, Marquette became a valuable and trusted member of the Clinical and Translational Science Institute and continued to expand its collaborations with CTSI entities.
Professor, Physiology and Human and Molecular Genetics
Director, Human and Molecular Genetics Center
Warren Knowles Chair in Genetics
Medical College of Wisconsin
Since 1996, Dr. Howard J. Jacob has served with distinction on the faculty of the Medical College of Wisconsin. Dr. Jacob is Professor of Physiology and Pediatrics; and Director of the Human and Molecular Genetics Center of MCW. He is the Warren P. Knowles Chair of Genetics at MCW.
Dr. Jacob received the PhD in Pharmacology at the University of Iowa and undertook postdoctoral training at Harvard and MIT. He was mentored, and later guided, by internationally recognized experts in pharmacology, cardiovascular physiology and genetics.
Dr. Jacob is recognized with this award for his extensive work in improving the health of patients and, for more than a decade, leading the development of the Human and Molecular Genetics Center into an internationally recognized research program geared to developing strategies to improve health. Taking advantage of comparative genomics between human, rat and mouse, Dr. Jacob has significantly advanced the understanding of the genetic determinants of renal disease and heart disease in humans.
Dr. Jacob has also experienced success in utilizing his research in developing technology transfer applications in various business settings intended to achieve positive health improvement results and resulting economic development. Last but not least, Dr. Jacob was instrumental in the development of the grant proposal that ultimately resulted in the federally funded CTSI of Southeast Wisconsin.
Medical College of Wisconsin
T. Michael Bolger served with distinction and significant accomplishment as the president of the Medical College of Wisconsin from 1990 to 2010. During that period of time, the MCW experienced an extraordinary period of growth including increase for faculty from 400 to 1,100; operating budget increased by 600% to over $850 million; $200 million of new facilities including the college’s Translational and Biomedical Research Center, Health Research Center and Cardiovascular Center/Anesthesiology research labs; three new doctoral programs; four new masters programs; joint programs with Marquette University and the Milwaukee School of Engineering; and expanded affiliation with Froedtert Hospital, Children’s Hospital of Wisconsin, BloodCenter of Wisconsin and Zablocki VA Medical Center.
Bolger achieved these changes and advancements in academic medicine with careful selection of talented people and a management style which created and maintained a positive and achievement oriented atmosphere.
Bolger encouraged and supported MCW faculty to expand funded research of $20 million in 1990 to over $145 million in 2010. The research initiative also included the successful creation and funding of the Clinical and Translational Science Institute which received a $20 million grant from the National Institutes of Health in 2010.
The John L. Doyne Collaboration Award was created to honor and preserve the legacy of former Milwaukee County Executive John L. Doyne as the “Father” of the Milwaukee Regional Medical Center.
John L. Doyne served as County Executive from 1960 to 1976. He was the public sector leader who brought private and public parties together in carrying out his lifelong vision of creating a regional medical center on County grounds located in Wauwatosa, Wisconsin.
As a result of his vision, abilities, personality and determination, the Milwaukee Regional Medical Center (MRMC) developed as a hub for advanced medical research as well as a provider of superior patient treatment and care. MRMC organizations continue to advance both the physical and economic health of this region by providing a diverse group of medical professionals and facilities serving over 1 million clients/patients, employing more than 20,000 people with family-supporting jobs, and creating an economic impact in the region far in excess of $3 billion per year.
8th Annual Viewpoint Luncheon: Opioid Epidemic – “Addressing our Community in Crisis Through Collaboration in Research and Discovery”
7th Annual Viewpoint Luncheon “Advancing the Health of Veterans through Collaboration in Research & Discovery”
The nonpartisan Public Policy Forum, established in 1913 as a good government watchdog, currently focuses its policy research on a broad range of issues affecting southeastern Wisconsin, the state and the nation. This research includes government finance and economic development policy, education, transportation, public safety, health, public infrastructure and other quality of life concerns.
The Forum serves the public, businesses, government and other interested constituencies by spotlighting trends, defining emerging issues and facilitating productive interaction among local governments and the private sector to promote sound and innovative policy solutions.
Fiercely independent and widely respected for its unbiased research, the Forum is a source of accurate information for local, state and national leaders seeking effective answers to public policy issues.
In addition to publishing annual research reports, Research Briefs, and Regional Reports, the Forum hosts discussions and programs on issues of local and regional interest.
October 27, 2014
Purchased by Milwaukee County in 1852 and exclusively occupied for a century by County institutions, the Milwaukee County Grounds in Wauwatosa now house one of the state’s foremost clusters of private health care institutions and businesses. Meanwhile, the County’s Mental Health Complex will soon shrink to fewer than 80 beds and its overall presence on the Grounds is vastly diminished.
Join the Public Policy Forum at a Viewpoint Luncheon that will explore Milwaukee County’s future at the County Grounds.
Our panel of government and private sector leaders includes:
Rob Henken, President, Public Policy Forum
Marquette University President, Michael Lovell, on collaboration at the UWM Innovation Campus
Greater Milwaukee’s economic development leaders are working on several initiatives to enhance the region’s competitiveness, including high-profile efforts to promote water and energy clusters, enhance academic research and nurture entrepreneurs.
Some are asking, however, whether we possess the high-performance computing infrastructure needed to achieve those and other economic development goals. How does our region measure up when it comes to IT infrastructure and why does it matter?
Who are the key players and who would supply the resources to expand our capacity? Overall, what will it take to build the IT infrastructure needed to compete for research dollars and knowledge workers in a 21st century global economy?
This Public Policy Forum Viewpoint Luncheon will explore Milwaukee’s information technology prowess and its importance to our regional economy.
Dr. Jay Bayne, Executive Director, Milwaukee Institute
David Crass, Director of Research Cyberinfrastructure, UW-Milwaukee
Tina M. Chang, Chief Executive Officer, SysLogic, Inc.
Nancy Olson, Chief Information Officer, City of Milwaukee
Kathleen Gallagher, Milwaukee Journal Sentinel
Greater Milwaukee is home to several colleges and universities, including four that collectively spend more than $200 million annually on research and development. How are those institutions transferring new discoveries to the commercial sector for public benefit? Would enhanced collaboration among the four produce greater dividends for our regional economy? What is the appropriate role of our colleges and universities in fostering economic growth and tackling the difficult issues facing our region?
This Public Policy Forum Viewpoint Luncheon discussed how our colleges and universities view their role in addressing Greater Milwaukee’s economic and social challenges.
John R. Raymond, MD, President & CEO, Medical College of Wisconsin
Hermann Viets, PhD, President, Milwaukee School of Engineering
Jeanne M. Hossenlopp, PhD, Vice Provost for Research and Dean of the Graduate School, Marquette University
Brian D. Thompson, President, University of Wisconsin – Milwaukee Research Foundation
Rob Henken President, Public Policy Forum5 MBDownload the 2011 MRRF Program Booklet
A new $20 million federal research grant awarded to Milwaukee-area research institutions to establish the Clinical and Translational Science Institute has generated new hope regarding our region’s research prowess. Now, many are asking whether the momentum can be sustained. What will it take to attract more federal research dollars to metro Milwaukee? What is the role of state and local government in promoting university research and encouraging economic spin-off? Can we build the high-tech infrastructure needed to successfully compete for research dollars and effectively reap the benefits of academic research?
Dr. Jay Bayne, Executive Director, The Milwaukee Institute
Dr. Marc Levine, Professor, UWM Center for Economic Development
Daniel Steininger, Co-Founder, BizStarts Milwaukee
Tom Still, President, Wisconsin Technology Council
Dr. Stephen L. Percy, Acting Dean, UWM School of Public Health and Director, UWM Center for Urban Initiatives and Research5 MBDownload the 2010 MRRF Program Booklet
The following posters were on display at the 2012 Milwaukee Regional Research Forum:
Objective: To find a combination of immune therapies that facilitate the identification of tumor cells as well as a robust activation of killer immune cells that result in unbounded tumor regression.
Investigators: Tyce Kearl, Jill Gershan, William Drobyski and Bryon Johnson
Objective: To design interventions to improve communication skills and specifically addressing challenges parents face in working with substitute care providers that could improve care.
Investigators: Mussatto K, Henriques J, Krolikowski M, Brosig Soto C, Melby J, Harrison T, Pridham K.
Objective: A comparison of VWF collagen binding (VWF:CB) and VWF multimer distribution was performed to evaluate the utility of VWF:CB as a diagnostic test.
Investigators: Veronica H. Flood, Joan Cox Gill, Kenneth D. Friedman, Pamela A. Christopherson, Paula M. Jacobi, Raymond G. Hoffmann, Robert R. Montgomery, and Sandra L. Haberichter
Objective: To determine which AP isoforms are prevalent in healthy and NEC neonates.
Investigators: Ben E. Biesterveld, Rebecca M. Rentea, Scott R. Welak, Diana G. Lerner, Katherine M. Fredrich, David M. Gourlay
Objective: To determine if vibro-tactile stimulation using stochastic resonance can enhance stroke survivors’ tactile sensation at the fingertips.
Investigators: Leah R. Enders, Na Jin Seo
Objective: To determine the role of the modulation of the intracortical inhibition (quantified as short-interval intracortical inhibition, SICI, using transcranial magnetic stimulation) in abnormally delayed grip relaxation after stroke.
Investigators: Binal Motawar, Na Jin Seo
Objective: To quantify the degree, type, and location of neural modulation during TMS to provide foundational information necessary to target, or avoid targeting, specific anatomical regions in the brain.
Investigators: Brian D. Goodwin, Manoj Raghavan, Klaus Driesslein, Christopher R. Butson
Objective: To optimize the current glove design using a biomechanical model that results in natural hand opening for stroke survivors.
Investigators: Pilwon Hur, Daniel Lomo-Tettey, Na Jin Seo
Objective: To determine whether a) single nucleotide polymorphisms (SNPs) in the TLR genes modulate susceptibility to sepsis in VLBW infants, and b) TLR SNPs modulate WBC counts obtained during culture-positive (C+ve) sepsis.
Investigators: Venkatesh Sampath, Neil P. Mulrooney, Jeffery S. Garland, Jie Ye, Aloka L. Patel, Jonathan D. Cohen, Pippa M. Simpson, Ronald N. Hines
Objective: To present a Common Sense Model (CSM) that sets the patient’s “model” of diabetes in a mobile computing framework where behaviors are easily and logically linked to disease outcomes through continuous monitoring of SMBG, heart rate, medications, diet, and exercise.
Investigators: Jay Urbain, Edith Burns, Paul Knudson, Megan Fedders, Bambi Wessel, William Klitzkie, Ann Swartz, Scott Strath
Objective: To understand the role of IL-27 in natural killer (NK) cell-based effector functions.
Investigators: Monica S. Thakar, Pawan Kumar, Kamalakannan Rajasekaran, Kristina Schuldt, Subramaniam Malarkannan
Objective: To identify protein signatures that are unique to each GBM patient; determine if they predict a differential response to Bevacizumab therapy and provide unique information for the development of new drug targets either in combination or as an alternative to Bevacizumab therapy.
Investigators: Maxime Heroux, Marla Chesnik, Mona Al Gizawiy, Elizabeth Cochran, Scott Rand, Jennifer Connelly, Wade Mueller, Mark Malkin, Kathleen Schmainda and Shama Mirza
Objective: To determine the role of stromal cell-derived factor 1 (SDF-1) and its cognate receptor chemokine receptor 4 (CXCR4) in the migration and rejuvenating effect of BMSC transplanted in an in vitro model of TBI.
Investigators: Aleksandra Glavaski-Joksimovic and Milan Joksimovic
Objective: To determine if radiation-induced intestinal radiation injury would be mitigated by oral IAP supplementation in an adult rat model.
Investigators: Rebecca M. Rentea, Vy Lam, Katherine Fredrich, Jennifer Callison, John E. Moulder, John E. Baker, David M Gourlay, Mary F. Otterson
Objective: To identify therapeutic agents that would be effective in treatment of the negative and cognitive symptoms of schizophrenia.
Investigators: Dana A. Ley, Joseph McGraw, Daniel Sem, Kambiz Pahlavan, Gunnar Larson, M. Behnam Ghasemzadeh
Objective: To determine if EET analogs would decrease cisplatin-nephrotoxicity.
Investigators: Md. Abdul H. Khan, Jessica L. Meyer, Katherine A. Walsh, John R. Falck, Jawahar L. Jat, Vijay L. Manthati, John D. Imig
Objective: To investigate the potential role of Nogo protein in CNS pathophysiology in the presence of hyperoxia. We hypothesize that Nogo proteins have a protective effect on neuronal and axonal development.
Investigators: Susan S. Cohen, Ru-Jeng Teng, Qing (Robert) Miao, G. Ganesh Konduri
Objective: To investigate whether an optical imaging technique to evaluate mitochondrial metabolic coenzymes, NADH and FAD will delineate oxidative stress from hyperoxia and LPS in neonatal rat lungs.
Investigators: Reyhaneh Sepehr, Annie L. Eis, Girija G. Konduri, Mahsa Ranji
Objective: To determine whether induced pluripotent stem cells (iPSCs) derived from BMD and DMD patients could be differentiated into cardiomyocytes and retain a specific disease phenotype.
Investigators: Jennifer L. Strande, Scott Canfield, Jennifer Meyer, Zeljko J. Bosnjak
Objective:To identify a proteomic-based peripheral blood biomarker panels in a serial and prospective monitoring strategy in HFpEF patients.
Investigators:Shama Mirza, Marla Chesnik, Courtney Van Dusen, and Jennifer L. Strande
Objective: To characterize the functional sources of upper limb tremor and dysmetria that occur in patients with Multiple Sclerosis (MS) using a systems identification approach together with a closed-loop model of sensorimotor control.
Investigators: Megan Heenan, Douglas Woo, Robert Scheidt, Julie Bobholz, Scott Beardsley
Objective: To evaluate a device that measures the oxidation of tissue metabolism using optical fluorescence techniques.
Investigators: Kevin Staniszewski, Reyhaneh Sepehr , Mahsa Ranji, Said H. Audi, Elizabeth R. Jacobs
Objective: To evaluate home oxygen use for pre-term infants with chronic lung disease.
Investigators: Joanne Lagatta, Reese Clark, David Brousseau, Raymond Hoffmann, Alan Spitzer
Objective: To determine if TCT can detect extracapsular extension of PCa.
Investigators: M Thomas, E Hanson, H Kelly, K Jacobsohn, W See, S Patch
Objective: To examine blue light irradiated MRSA colonies at the molecular level by observing the effect of blue light on femA and mecA genes implicated in antibiotic resistance; analyzing the protein profile of whole cell lysates and genomic fingerprinting using Pulsed field gel electrophoresis (PFGE) and Diversilab repPCR.
Investigators: Bumah VV, Masson-Meyers DS, Bhattacharyya S, Khubbar M, Gradus S, Whelan H & Enwemeka CS
Objective: To elucidate whether NI-hMSCs can be differentiated into the dopaminergic (DA) neuronal subtype.
Investigators: Ryan Funk, Arshak R. Alexanian
The following posters were on display at the 2011 Milwaukee Regional Research Forum:
Objective: To develop a better understanding of neuromuscular defects and hence improve function in patients with multiple sclerosis
Investigators: Chua, Matthew, PhD (MU), Hyngstrom, Allison, PT, PhD (MU), Ng, Alexander, PhD (MU), Woo, Douglas MD (MCW), Schmit, Brian D., PhD (MU)
Objective: To develop a model, using a systems identification approach, to characterize the functional sources of upper limb tremor and dysmetria in patients with multiple sclerosis
Investigators: Beardsley, Scott, PhD (MU), Scheidt, Robert, PhD (MU), Woo, Douglas, MD (MCW) and Bobholz, Julie, PhD (MCW)
Objective: To develop a sensitive and efficient non-invasive imaging method to identify the extent of surgically resectable lesions in patients with brain tumors
Investigators: Gaggl, Wolfgang, MSEE (MCW) and Prost, Robert W., PhD (MCW)
Objective: To examine the neural pathways responsible for “neuromuscular fatigue” and their relationship to ambulation in post-stroke patients
Investigators: Hyngstrom, Allison, PhD (MU), Keenan, Keith, PhD (UWM), Nelson, Philip A. MD (MCW), Hunter, Sandra, PhD (MU), and Schmit, Brian, PhD (MU)
Objective: To enhance the understanding of how the brain controls movements in people with and without stroke, with the long term objective of providing a scientific rationale for the development of more effective interventions
Investigators: Schindler-Ivens, Sheila, PT, PhD (MU), Johnson, Michelle J. PhD (MCW), Kamara, Sheku (MSOE), Wang, Jinsung, PhD (UWM), Bao, Shancheng (MU)
Objective: To evaluate a genetically regulated molecular mechanism affecting learning behavior and memory in a mouse model
Investigators: Pan, Bin, MD (MCW), Wang,Wei (MCW), Zhong, Peng (MCW), Blankman, Jacqueline L. (Scripps Research Institute), Cravatt, Benjamin F., PhD (Scripps Research Institute) and Liu, Qing-song, PhD (MCW)
Objective: To identify the genetic mechanism of congenital glaucoma in a patient with a novel genetic mutation
Investigators: Schilter, Kala F. (MCW), Reis, Linda M. (MCW) and Semina, Elena V., PhD (MCW)
Objective: To evaluate the neural and behavioral correlates of a specific genetic mutation that may be associated with dyslexia
Investigators: Conant, Lisa L., PhD (MCW), Graves, William W., PhD (MCW), Osmon, David C., PhD (UWM), Binder, Jeffrey R., MD (MCW)
Objective: To develop a novel model for isolating lymphatic endothelial cells from patients with lymphatic malformations to enable future identification of genes contributing to these malformations
Investigators: Duffy, Kelly, PhD (MCW), Johnson, Craig, DO (MCW), Samant, Ganesh, PhD (MCW), Santoro, Jennifer (MCW), Ramchandran, Ramani, PhD (MCW)
Objective: To evaluate the effectiveness of phenothiazines (anti-psychotic drugs) in a mouse model of infections caused by methicillin resistant staphylococcus aureus
Investigators: Sohnle, Peter G., MD, (MCW) and Hahn, Beth L. (MCW)
Objective: To develop specific therapeutic targets, based on the pathophysiology of lung injury, in patients with acute lung injury
Investigators: Jeziorczak, Paul M., MD (MCW), Kaul, Sushma, MSc, MS (MCW), Pritchard, Jr., Kirkwood A., PhD (MCW), Oldham, Keith T., MD (MCW), Jacobs, Elizabeth R., MD (MCW), and Densmore, John C., MD (CHW)
Objective: To develop the use of single-photon emission computed tomography (SPECT) imaging agents as non-invasive biomarkers of cell death and changes in redox status in early lung disease/injury
Investigators: Clough, Ann V., PhD (MU), Audi, Said, PhD (MU), Roerig, David L., PhD (MCW), Haworth, Steven T., PhD (MCW) and Jacobs, Elizabeth R., MD (MCW)
Objective: To investigate the molecular mechanisms of the synergistic in-vivo toxicity of radiotherapy and celecoxib, a non-steroidal anti-inflammatory drug, as applied in the treatment of patients with squamous cell carcinoma of the head and neck, a very high-mortality cancer.
Investigators: Bock, Jonathan M., MD (MCW) and You, Ming, MD, PhD (MCW)
Objective: To evaluate the relationship between psychosocial factors and clinical outcomes in bone marrow transplant recipients
Investigators: Knight, Jennifer M., MD (MCW), Moynihan, Jan A., PhD (University of Rochester), Lyness, Jeffrey M., MD (University of Rochester), Xia, Yinglin, PhD (University of Rochester), Tu, Xin, PhD (University of Rochester), Hunter, Bryan C. PhD, LCAT, MT-BC (Nazareth College), Huang, Li-Shan PhD (University of Rochester), Obi, Rosemary O. MS, LCAT, MT-BC (University of Rochester), Gaisser, D’Arcy MS, APRN, (University of Rochester), Liesveld, Jane L. MD (University of Rochester) , Sahler, Olle Jane Z., MD (University of Rochester)
Objective: To understand the genetic basis of one form of chronic renal injury (interstitial fibrosis) in the human kidney
Investigators: Kriegel, Alison, PhD (MCW), Mladinov, Domagoj (MCW), Kelly, Holly (MCW), Langenstroer, Peter, MD (MCW), See, William, MD (MCW), Liang, Mingyu, PhD (MCW)
Objective: To study intracellular mechanisms underlying renal tubular epithelial cell proliferation and tubular repair following ischemia-reperfusion injury
Investigators: Regner, Kevin R., MD (MCW), Nozu, Kandai, PhD (MCW), Lainier, Stephen M., PhD (Medical University of SC, Charleston), Blumer, Joe B. PhD (Medical University of SC, Charleston), and Avner, Ellis D.MD (MCW)
Objective: To develop a human model of dystrophic cardiomyopathy in order to study the underlying mechanisms responsible for cardiomyocyte failure and to validate this model as a tool for drug discovery
Investigators: Strande, Jennifer L. MD, PhD (MCW) and Bosnjak, Zeljko J. PhD (MCW)
Objective: To evaluate a hormonal marker that would predict the development of left ventricular dysfunction in children receiving anthracycline chemotherapy
Investigators: Gudausky, Todd M., MD (MCW) and Tower II, Richard L., MD, MS (MCW)
Objective: To compare the associations of different gender-based adiposity distributions on cardiovascular disease risk factors in African American women and men
Investigators: Kidambi, Srividya, MD (MCW), Coly, Gerard, MD (MCW), Widlansky, Michael, MD (MCW)
Objective: To determine if genetic manipulation of vascular epoxyeicosanoids (EETs) improves vascular function in insulin resistant and obese mice
Investigators: Walsh, Katherine M. (MCW), Imig, John D., PhD (MCW)
Objective: Investigating Near Infra Red Spectroscopy (NIRS) for assessing tissue oxygenation in patients with acute respiratory distress syndrome following a life-threatening injury.
Investigators: Ranji, Mahsa, PhD (UWM), Jacobs, Elizabeth, MD (MCW), Audi, Said, PhD (MU)
Objective: Novel chemical probes and synthetic peptides are applied to investigate the role of reactive oxygen species produced in rat lungs as a result of infection and high oxygen concentration.
Investigators: Konduri, Girija Ganesh, MD (MCW), Jacobs, Elizabeth, MD (MCW), Pritchard, Jr., Kirkwood A., PhD (MCW), Ranji Mahsa, PhD (UWM), Audi, Said, PhD (MU)
Objective: To develop a “smart phone” to assist diabetic patients with self-monitoring of blood glucose
Investigators: Urbain, Jay, PhD (MSOE), Burns, Edith, MD (MCW), Knudson, Paul, MD (MCW), Fedders, Megan, MS (MCW), Wessel, Bambi, MA (MCW), Strath, Scott, PhD (UWM), and Swartz, Ann, PhD (UWM)
Objective: To introduce high school students to the process of science through the creation of physical models of proteins by rapid prototyping technology
Investigators: Colton, Shannon, PhD (MSOE), Franzen, Margaret, PhD (MSOE), Hoelzer, Mark (MSOE) and Herman, Tim, PhD (MSOE)
Objective: To investigate the efficacy of delivering healthcare services in the 3D virtual world called Second Life that simulates the real world in order to increase access to and reduce the cost of healthcare
Investigators: Zahedi, F.Mariam, DBA (UWM), Shaker, Reza, MD (MCW), Jain, Hemant, PhD (UWM), Walia, Nitin, PhD (UWM)
Objective: To develop a centralized database to better understand the high prevalence of poor birth outcomes in southeastern Wisconsin
Investigators: Eldredge, Christina, MD (MCW), Slawson, James, MD (MCW), Granados, Rodolfo (MCW), Payne, Judy (MCW)
Objective: To determine if discontinuation of a nurse protocol in the Emergency Department changes (1) the proportion of children receiving an analgesic and (2) the timeliness of analgesic administration
Investigators: Kelly, Brian T., MD (MCW), Friend, Tiama, MD (MCW) and Drendel, Amy L., DO, MS (MCW)
Objective: To evaluate the feasibility, reliability, validity, and responsiveness of the acute version of the Pediatric Quality of Life Inventory scales after Emergency Department care of minor injury
Investigators: Stevens, Martha W., MD (MCW), Hainsworth, Keri R., PhD (MCW), Weisman, Steven J, MD (MCW) and Layde, Peter M., MD, MPH (MCW)
Objective: To improve the effectiveness of the internet as a vehicle for communication between community and academic partner
Investigators: Nelson, David, PhD, MS (MCW), Opel, Shannon, MPH (MCW), Kissack, Anne, MPH, RD (MCW), Granados, Ody, BA (MCW) and Ahmed, Syed, MD, MPH, Dr.PH (MCW)
Objective: To showcase the new M.S. Program in Clinical & Translational Science that offers both education and application opportunities in two broad areas of emphasis, i.e., Translational Research, and Commercial Development of Drugs, Biologics, Devices, and Diagnostics
Authors: Kusch, Jennifer, PhD (MCW), Kotchen, Jane, MD, MPH (MCW), Hefti, Arthur, DDS, PhD (Marquette University), Chelius, Tom, MS (MCW), Erby, Chaunté (MCW)