Adult Translational Research Unit

Adult Translational Research Unit (TRU)

The Adult Translational Research Unit (TRU) is designed to provide an optimal clinical research environment for both research participants and translational investigators. The TRU provides the infrastructural support for the conduct of clinical and translational research projects by providing access to space, resources and the expertise of research support personnel.

The TRU provides a safe, controlled environment for investigators to conduct state-of-the-art patient-oriented studies. The unit is designed to support a wide range of clinical research, from pilot studies to multi-center clinical trials.

Contact Information

414-805-7300
Email the Adult TRU

Overview

Overview

Scientists at the Medical College of Wisconsin and at any of the CTSI partner institutions who have an approved protocol can utilize the TRU facilities.  We provide support services for a diverse array of research studies, which involve pulmonary, cardiovascular, chronic kidney, neurological (Alzheimer’s), metabolic, sickle cell, genetics and rare diseases to include a few.

The Adult TRU is located in close proximity to the main entrance of the Pavilion building of Froedtert Hospital. The unit is able to provide a wide array of basic clinical research services including nursing support, dedicated nursing time, use of exam rooms and equipment, laboratory sample preparation and consultations. Special arrangements can be made for studies requiring TRU support in a hospital setting.

Services

Services

The A-TRU team is available to assist with a variety of services including :

Nursing Clinical

  • Vital Signs, Height and weight measurements
  • Phlebotomy services
  • IV placement and monitoring
  • Standard of Care lab draws
  • Blood processing (refrigerated centrifuge available)
  • Sample storage (refrigerated, -20 degree Celsius, and -80 degree Celsius freezer)
  • Long Term sample storage for banking (-80 degree Celsius freezer)
  • IATA Certified Sample shipping (ambient and dry ice)
  • Batch Sample shipping and inventory
  • Urine Dipstick (protein and glucose)
  • Point of Care (POC) urine pregnancy, cotinine, and drug testing
  • Point of Care Glucometer Reading
  • POC HgbA1C determination
  • Study Drug administration and monitoring (IV, PO, IM, SQ)
  • 12 Lead EKG (needs cardiology interpretation)
  • 6 Minute Walk Test
  • Epithelial nasal cell collection
  • Saliva collection and processing for cortisol levels
  • Sweat collection
  • Urine processing (24 hour collection and lab sampling)
  • MRI contrast infusion and monitoring
  • Contrast enhanced ultrasound infusion and monitoring
  • Breath testing specimen collection
  • Telephone interviews and post-procedure follow-up phone calls
  • Laser Doppler Velocity readings
  • Glucose Tolerance Test administration and blood draws
  • Assist with bedside procedures: Lumbar puncture, adipose biopsy, J-Wire insertion.

 

Administrative, Non-Clinical

  • Laboratory Data Management Software(LDMS):data entry
  • Appointment scheduling
  • Set up charts
  • EPIC labels
  • Order supplies
  • Laboratory requisition completion for Wisconsin Diagnostics, Quest Laboratories, and specific sponsor supported studies
  • Meal orders for participants and guests
  • Assembly of study specific supply kits

Hours of Operation

Hours of Operation

Monday – Friday: 7:30 a.m. – 4:30 p.m.
*Additional timeslots are available by special appointment. Please contact the TRU for appointments.

Fees - TRU Clinical Services

Fees – TRU Clinical Services

TRU Clinical Services

  • Inpatient / Campus Clinical Services
  • Dedicated 1:1 / Staff:Participant
  • Protocol execution as described in Letter of Agreement
  • Check-in and room use
  • Snacks and meals for use over two hours
  • Clinical equipment & supplies – usual and customary
  • Clinical staff – basic or complex services as defined in the Wisconsin Nurse Practice Act and MCW job descriptions for Registered Nurse and/or Medical Assistant II, and Laboratory Technician
  • When applicable, mileage is invoiced at the current IRS rate

Hourly rates are invoiced at 15 minute increments

Monday – Friday 7:30 a.m. – 4:30 p.m.

Non-profit

$40/hour

For Profit

$60/hour

After hours and weekends

Non-profit

$60/hour

For Profit

$60/hour

Protocol Start-up (stand-alone protocols only)

  • Document Review (protocol; IRB; eBridge; consent; etc.)
  • Coordination (meetings; communications; etc.)
  • Administration (cost estimate; Letter of Agreement)

One time fee (rate will depend on the complexity of the protocol)

Non-profit

$350/$500

For Profit

$500/$1000

Protocol Set-up (all protocols)

  • Clinical Flowsheet creation and PI verification
  • Staff orientation and education
  • Site selection visits
  • Equipment certifications
  • Tour of facilities
  • REDCap project setup

Hourly rates are invoiced at 15 minute increments

Non-profit

$40/hour

For Profit

$60/hour

Community Nursing

  • Clinical/lab equipment & supplies (usual and customary)
  • Scope of services to be determined upon review of project

Hourly rates are invoiced at 15 minute increments

Non-profit

$40/hour

For Profit

$60/hour

TRU Scheduling Fee

  • Participant Coordination (scheduling; check-in; etc.)
  • Room use and set-up
  • Clinical equipment & supplies (usual and customary)

Non-profit

$10/visit

For Profit

$20/visit

EKG (uninterpreted)

  • Applicable when only as stand-alone procedure: if part of larger visit, will be charged hourly under ‘clinical services’

Non-profit

$20 flat fee

For Profit

$40 flat fee

Lab Access Only (24/7)

  • Only when using lab exclusively; not associated with a clinic visit
  • Access and use of centrifuge and other routine equipment
  • Access and use of Refrigerator, -20 Freezer, -80 Freezer (not banking or long-term storage)
  • Usual and customary lab supplies

Non-Profit

$5/use

For Profit

$10/use

Phlebotomy

  • Applicable when only as stand-alone procedure: if part of larger visit, will be charged hourly under ‘clinical services’

Non-profit

$15 flat fee

For Profit

$30 flat fee

Sample Storage

  • Storage in -80 freezer, -20 freezer, or refrigerator
  • Banking and long term storage
  • Price includes up to 50 boxes

Non-profit

$100/year

For Profit

$200/year

Sample Storage Inventory

  • Logging of samples
  • Boxing
  • Inventory management
  • Shipping

Hourly rates are invoiced at 15 minute increments

Non-profit

$40/hour

For Profit

$60/hour

Fees - Bionutrition Services

Fees – Bionutrition Services

ServiceDescription of ServicesNon-ProfitFor-Profit
General Bionutritional Clinical ServicesParticipant Coordination (scheduling, check-in)
Room use and set-up
Snacks and meals for use over two hours
Clinical/lab equipment & supplies (usual and customary)
Hourly rates invoiced at 15 minute increments; mileage invoiced at current IRS rate, when applicable.
Monday – Friday 7:30 a.m. – 4:30 p.m.
$40/hour$60/hour
After hours and weekends$60/hour$60/hour
Protocol Start-Up (Stand-Alone Protocols Only)Document review (protocol; IRB; eBridge; consent; etc.)
Coordination (meetings; communications; etc.)
Administration (cost estimate; Letter of Agreement)
$250$500
Protocol Set-Up (All Protocols)Clinical flowsheet creation and PI verification
Staff orientation and education
Site selection visits
Equipment certifications
Tour of facilities
REDCap project setup
$40/hour$60/hour
AnthropometricsHeight; weight; waist; hip; thigh
Multiple site measurements
Averages
BMI
Waist to hip ratios calculated
Skinfold measurements performed by a skilled technician
Population specific equations calculated with references
$40/hour$60/hour
Data ManagementDocumentation of Bionutrition measurements
Exporting and importing data into secure databases (e.g. REDCap)
Quality assurance checks of data; submissions; etc.
$40/hour$60/hour
Dietary AssessmentNutrition Screen: nutritional risk & status evaluation
24 Hour Recall & Food Record Keeping (including food record materials with instructions)
Nutrient analysis using NDRS
Food Frequency questionnaires
$40/hour$60/hour
Indirect Calorimetry Analysis (Resting Metabolic Rate)Resting Energy Expenditure (REE) & Respiratory Quotient$40/hour$60/hour
Community Testing Rate
$60 first test
$50 repeat test
Lifestyle CounselingConsultation focused on compliance w/dietary protocols, goal setting, social support, stimulus response & self-efficacy improvement approaches$40/hour$60/hour
Research Meal ServicesResearch Meal Design
Participant consultation and assessment
NDSR macronutrient and micronutrient controlled meals and complete menus
Menu materials printed
Research Meal/Snack Preparation
Grocery shopping
Food and supply ordering
Preparation
Portioning
Packaging of meals
Clean up, etc.
Research Meal Food & Supply
Cost varies per food cost; ingredients; “to go” packaging (pass through)
Research Meal Delivery
Cost is for time for delivery plus mileage per current IRS rates
$40/hour$60/hour
Bioelectric ImpedanceTotal, extracellular, intercellular body water measurement, lean mass, and percent fat body measurement
Hourly rate invoiced at 15 minute increments
$25/hour$50/hour
DXA ScansTotal body composition and/or bone mineral density testing (AP Spine and Dual Femurs)$40/hour$60/hour
Female participants may require a pregnancy test$5$10
Technician fee
Hourly rate invoiced at 15 minute increments
$40/hour$60/hour
Community
$120 first scan
$80 repeat scan
TRU Facility UseParticipant Coordination (scheduling, check-in)
Room use and set-up
Clinical/lab equipment & supplies (usual and customary)
Hourly rate invoiced at 15 minute increments
$10/hour$20/hour
Fees - Lab Services

Fees – Lab Services

Prices are subject to change without notice.

TRU POC - Translational Research Unit Point of Care
For Wisconsin Diagnostics pricing, please contact Tanya Aigner at 414-805-7300.

 
LabServiceNon-Profit SponsorFor-Profit Sponsor Description of Services
Core Lab1, 25-Dihydroxy-Vitamin D3 (RIA)$44.00
Core Lab25-OH Vitamin D3 (ELISA)$31.05
Core Lab25-OH-vitamin D3 (RIA)$48.25
Core LabACE (Angiotensin Converting Enzyme)$11.00
Core LabACTH IRMA$28.45
Core LabAdiponectin$26.40
Core LabAldosterone$22.80
Core LabAngiotensin II$42.20
Core LabBDNF (Brain-derived Neurotrophic Factor)$32.60
Core LabBNP (Brain Natriuretic Peptide)$32.60
Core LabC-Peptide$23.20
Core LabC-Reactive Protein (hs)$23.30
Core LabcAMP (Cyclic AMP)$57.00
Core LabCCK (Cholecystokinin)$42.90
Core LabCd40$36.00
Core LabCholesterol$9.30
Core LabCholesterol (HDL & LDL)$13.30
Core LabCortisol (serum)$24.20
Core LabCSF (G, M, or GM) (Colony-stimulating factor, granulocyte, macrophage)$32.60/each
Core LabDHEAS (Dehydroepiandrosterone sulfate)$14.00
Core LabDNA, buccal (all other)$28.80
Core LabDNA, buccal (Oragene kits)$40.00
Core LabDNA, dilutions$1.20
Core LabDNA, fresh blood$22.50
Core LabDNA, frozen blood$33.60
Core LabE-Cadherin$36.00
Core LabEGF (Epidermal growth factor)$32.60
Core LabEndothelin-1$32.60
Core LabeNOS (Endothelial nitric oxide synthase)$32.60
Core LabEstradiol$12.00
Core LabEstrone$33.10
Core LabFerritin$12.00
Core LabFetuin A$32.60
Core LabFGF (Fibroblast growth factor)$32.60
Core LabFree Fatty Acids$17.40
Core LabFSH (Follicular stimulating hormone)$12.00
Core LabGhrelin$26.00
Core LabGLP-1 (7-36) (Glucagon-like peptide, residues 7-36)$18.00
Core LabGlucagon$34.80
Core LabGlucose$5.00
Core LabHGH (Human growth hormone, normal sensitivity)$12.00
Core Labhsp27 (Heat shock protein 27)$33.00
Core LabIGF-1 (Insulin-like Growth factor)$24.00
Core LabIGFBP-3 (IGF Binding protein 3)$40.00
Core LabInsulin$16.00
Core LabInterleukin-6 (Also Interleukin 1a, 1b, 2, 8, 10, 12)31.50/each
Core LabiPTH (Parathyroid hormone, intact)$25.40
Core LabLeptin$16.00
Core LabLH (Luteinizing hormone)$12.00
Core LabLipid panel (total cholesterol, HDH chol., calculated LDL chol., triglycerides)$25.60
Core LabMelatonin$48.00
Core LabMMP or proMMP (Matrix, metalloproteinase, or its proenzyme)$32.60/each
Core LabNpY (Neuropeptide Y)$55.00
Core LabNT-proBNP (N-terminal prohormone of BNP)$66.00
Core LabOsteocalcin$50.20
Core LabOsteopontin$32.60
Core LabPA-1 (Plasminogen activator inhibitor-1)$33.00
Core LabPP (Pancreatic polypeptide)$42.90
Core LabProgesterone$12.00
Core LabProinsulin$20.00
Core LabPTH, total (Parathyroid hormone, total)$46.00
Core LabPYY (Peptide YY)$25.40
Core LabRBP-4 (Retinol-binding protein 4)$42.70
Core LabRelaxin-2$32.60
Core LabRenin, active plasma$28.60
Core LabResistin$32.60
Core LabS100-beta (total)$83.71
Core LabsE-Selectin$32.60
Core LabSerum Amyloid A$32.60
Core LabSHBG (Sex hormone binding globulin)$20.00
Core LabsICAM-1 (Serum intercellular adhesion molecule 1)$32.60
Core LabsVAM-1 (Serum vascular cell adhesion protein 1)$32.60
Core LabsVEGF (Serum vascular endothelial growth factor)$32.60
Core LabsVEGF receptors$32.60
Core LabTestosterone, free$16.60
Core LabTestosterone, total$12.00
Core LabTGF (Alpha or beta) (Transforming growth factor)$32.60/each
Core LabThrombopoietin$32.60
Core LabThrombopoietins 1 or 2$32.60/each
Core LabTNF-alpha (Tumor necrosis factor-alpha)$30.00
Core LabtPA (Tissue plasminogen activator)$32.60
Core LabTRAIL (TNF-related apoptosis-including ligand)$32.60
Core LabTriglycerides$8.70
Core LabTroponin I$20.60
Core LabTSH (Thyroid stimulating hormone, normal sensitivity or high sensitivity)12.00/each
Core LabVasopressin (AVP, or Arginine vasopressin)$50.60
Core LabvE-Cadherin$36.00
TRU POCEKG (UNINTERPRETED and INTERPRETED)Clinical Services Rate per HourClinical Services Rate per Hour
  • Per Test per Participant

  • Interpretation may be billed separately by the MCW Cardiovascular Center
TRU POCGlucose$5$10
  • Per Test per Participant ($10/50)
TRU POCHgA1C$10$20
  • Per Test per Participant ($310/40)
TRU POCUrine Cotinine$5$10
  • Per Test per Participant ($61/40)
TRU POCUrine Drug Screen$25$50
  • Per Test per Participant ($595/25)

  • Includes: Phencyclidine (PCP), Benzodiazepines, Cocaine, Amphetamines, THC, Opiates, Barbiturates, Tricyclic Antidepressants
TRU POCUrine Glucose$5$10
  • Per Test per Participant

  • Urine Dipstick-Range: 0/Tr/100/250/500/1000/2000
TRU POCUrine hCG$5$10
  • Per Test per Participant ($43/25)
TRU POCUrine Protein$5$10
  • Per Test per Participant

  • Urine Dipstick-Range: 0/Tr/30/100/300/2000
TRU Terms & Attestations

TRU Terms & Attestations

Terms

  • The TRU requires a fully signed Letter of Agreement (LOA), a study roll-out meeting, and a copy of the Institutional Review Board (IRB) Approval letter before the study may begin.
  • Cancellation of Requested Services: Please provide notice of at least 48 hours for cancellation of requested services.
  • Scheduling of Requested Services: Please email tru_scheduling@ chw.org to set up a study appointment. Availability is to the best of our ability with variables including but not limited to: already scheduled services for this or any other study, availability of appropriate staff, and availability of appropriate physical space.
  • The TRU fees are subject to change. Every effort will be made to minimize the amount and frequency of such changes.
  • As a practice, the TRU will maintain study documentation in EPIC. It is up to the individual study team to create and maintain their own source documents per their study requriements. Notify TRU RNs if certain elements need to be added to the EPIC progress note (i.e. vial number or kit lot numbers). If any additional documents outside of EPIC are kept in the PTRU, they will be turned over to the Principal Investigator at the time of study completion in the PTRU.
  • As a CTSI Investigator, you agree to participate in the TRU’s annual satisfaction survey process.
  • Should additional services be requested, a new proposal may be created to outline the scope of the request and associated cost-sharing fees. This LOA will be amended as necessary.
  • If any changes are made in your protocol, it is the study team’s responsibility to provide any updated IRB approved forms and review any procedural changes with the PTRU Nurse Manager prior to the next participant’s scheduled visit.
  • The TRU will bill on a monthly basis for all services rendered.
  • Payment for services performed will be expected upon receipt of a billing statement.

Attestations

  • On behalf of the department/division/institute or other professional jurisdiction that you represent, you attest that all of the following conditions have been satisfied:
    • The Principal Investigator is a faculty member, credentialed physician, licensed nurse or licensed pharmacist (as applicable) in good standing;
    • The Principal Investigator is approved to devote the proposed time and effort to this project;
    • If the Principal Investigator’s application identifies Department/Division/Institute funds to support this project, this Department/Division/Institute endorses this commitment;
    • The project has scientific merit, uses procedures consistent with sound research design, and is likely to yield the expected knowledge; and
    • The proposal is a complete and coherent one.
  • You agree to cite the Pediatric TRU of Children’s Hospital of Wisconsin on all publications arising from any research project receiving support from the PTRU.
  • If you are funded by a CTSI award, you agree to cite CTSA NIH Grant UL1TR001436 and if applicable KL2TR001438 on all publications arising from any research project receiving support from the CTSI. Publications arising from any research project receiving support from the CTSI must acknowledge such support by stating the following:
    • “Support received by grant UL1TR001436 from the Clinical and Translational Science Award (CTSA) program of the National Center for Advancing Translational Sciences.”
    • KL2 Scholars: “Support received by grants UL1TR001436 and KL2TR001438 from the Clinical and Translational Science Award (CTSA) program of the National Center for Advancing Translational Sciences.”

Request Services

Please note, we have centralized the requests for services for the service cores listed below. You no longer need to submit a separate request forms for each core, if you are using more than one.

  • Adult TRU
  • Pediatric TRU
  • VA TRU
  • Community TRU
  • Mobile TRU
  • TRU Core Lab
  • CTSI Clinical Trials Office
  • Biostatistics
  • Bionutrition Services

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ADULT TRU CORES

CTSI Investigators can also access the following cores located within the A-TRU.

NIH Funding Acknowledgment: Important Reminder – Please acknowledge the NIH when publishing papers, patents, projects, and presentations resulting from the use of CTSI resources by including the NIH Funding Acknowledgement.

PARTNERS

Zablocki VA Medical CenterMedical College of WisconsinMSOE