Ensemble Program Achievements

Since the program’s inception in 2019, the Ensemble program has had a variety of notable accomplishments, and these are tracked according to the following:

  • Team output, such as grant awards, publications, presentations, development of medical devices, patents, and exposure in news and media outlets
  • Team impact, such as clinical trials conducted, community interventions, changes to clinical process, and improved patient outcomes
  • Team efforts, engagement and the number of grants and manuscripts submitted

Collective Accomplishments

grants submitted ($54.2M total)
Local and National Presentations
learners engaged
Ensemble Products Totals
Grants 24 grants submitted ($54.2M Total)
2 grants funded ($1.9M; $300K)
3 grants pending review
Research Participants Enrolled Veterans Exercise Ensemble Pilot Intervention: 14 participants
Surveys Conducted 7 surveys
1 Pre-Ensemble: 1 survey 322 responses
IRB & IBC Protocols 19 approved IRB or IBC
1 pending IRB or IBC
Publications 40 Publications
161 Citations
Local & National Presentations 31
Devices & Procedures Handheld Ultrasound Device
Continence Muscle Resistance Measurement Device
New Animal  Model 1 Food insecurity rat model
Learners Engaged 66 Students and/or Trainees

Ensemble Research Dissemination

Funded February 1, 2020

Data Science for Precision Medicine Ensemble: 3 Publications

Luo J, Tong L, Crotty BH, Somai M, Taylor B, Osinski K, George B. Telemedicine Adoption during the COVID-19 Pandemic: Gaps and Inequalities. Appl Clin Inform. 2021 Aug;12(4):836-844. doi: 10.1055/s-0041-1733848. Epub 2021 Sep 8. PMID: 34496419; PMCID: PMC8426040 Cited by 21 publications

Poetker DM, Friedland DR, Adams JA, Tong L, Osinski K, Luo J. Socioeconomic Determinants of Tertiary Rhinology Care Utilization. OTO Open. 2021 Apr 16;5(2):2473974X211009830. doi: 10.1177/2473974X211009830. PMID: 33948528; PMCID: PMC8053774 Cited by 1 publication

Zimmermann MT, Mathison AJ, Stodola T, Evans DB, Abrudan JL, Demos W, Tschannen M, Aldakkak M, Geurts J, Lomberk G, Tsai S, Urrutia R. Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level. Front Oncol. 2021 Mar 5;11:606820. doi: 10.3389/fonc.2021.606820. PMID: 33747920; PMCID: PMC7973372 Cited by 1 publication

Fecal Incontinence Ensemble: 6 Publications
Krupa Patel, Ling Mei, Navjit Lehal, Adam Benjamin, Patrick Sanvanson, Mark Kern, Reza Shaker. External anal sphincter strength training exercise using a novel continence muscles resistance exerciser device results in improved anal sphincter contractility in patients with fecal incontinence (PDF). Gastroenterology, Vol. 158, Issue 6, S-388 Cited by 2 publications

Krupa Patel, Ling Mei, Mark Kern, Patrick Sanvanson, Navjit Lehal, Francis O. Edeani, Reza Shaker. Geometric characteristics of the anal canal high-pressure zone during repetitive contraction against a resistive load can help define the fatigability of muscles involved in fecal incontinence (PDF). Gastroenterology, Vol. 158, Issue 6, S-388 Listed on same publication as above

Ling Mei, Krupa Patel, Navjit Lehal, Mark Kern, Adam Benjamin, Patrick Sanvanson, Reza Shaker. Fatigability of external anal sphincter muscles during various exercise methods using a novel strength training resistance exercise device. Gastroenterology, Vol. 158, Issue 6, S-385 Cited by 2 publications

Mei L, Patel K, Lehal N, Mark K, Benjamin A, Sanvanson P, Shaker R. Fatigability of the External Anal Sphincter Muscles Using a Novel Strength Training Resistance Exercise Device. Am J Physiol Gastrointest Liver Physiol. 2021 Apr 1;320(4):G609-G616. doi: 10.1152/ajpgi.00456.2020. Cited by 2 publications

Patel K, Mei L, Yu E, Kern M, Lehal N, Edeani F, Sanvanson P, Davidson ERW, Shaker R. Differences in fatigability of muscles involved in fecal continence: Potential clinical ramifications. Physiol Rep. 2021 Dec;9(24):e15144. doi: 10.14814/phy2.15144. PMID: 34927399; PMCID: PMC8685596. Cited by 8 publications

Patel K, Mei L, Lehal N, Sanvanson P, Kern M, Shaker R. Fatigability of the puborectalis muscle by repetitive anal contractions against the continence muscles resistance exerciser device (PDF). May 2021 Gastroenterology, Volume 160, Issue 6, S-500 – S-501. Cited by 0 publications
Multiple Myeloma Ensemble: 12 Publications
Cheng Y, Sun F, D’Souza A, Dhakal B, Pisano M, Chhabra S, Stolley M, Hari P, Janz S. Autonomic nervous system control of multiple myeloma. Blood Rev. 2021 Mar;46:100741. doi: 10.1016/j.blre.2020.100741. Epub 2020 Aug 11. PMID: 32807576; PMCID: PMC7876165. Cited by 8 publications

Dhakal B, D’Souza A, Kleman A, Chhabra S, Mohan M, Hari P. Salvage second transplantation in relapsed multiple myeloma. Leukemia. 2021 Apr;35(4):1214-1217. doi: 10.1038/s41375-020-1005-8. Epub 2020 Aug 4. PMID: 32747684; PMCID: PMC8020391. Cited by 10 publications

Dhakal B, Janz S. Myeloma sleeper agent in myeloid disguise. Blood. 2019 Jul 4;134(1):3-4. doi: 10.1182/blood.2019001273. PMID: 31273002. Cited by 2 publications

Dhakal B, Miller S, Rein L, Pathak LK, Gloria L, Szabo A, Giri S, Chhabra S, Hamadani M, Paner A, Padmanabhan A, Janz S, D’Souza A, Hari P. Trends in the use of therapeutic plasma exchange in multiple myeloma. J Clin Apher. 2020 Aug;35(4):307-315. doi: 10.1002/jca.21798. Epub 2020 Jun 9. PMID: 32516865. Cited by 2 publications

Dhakal B, Narra RK, Giri S, Szabo A, Smunt TL, Ghose S, Pathak LK, Aryal M, Hamadani M, Chhabra S, Janz S, D’Souza A, Hari PN. Association of adverse events and associated cost with efficacy for approved relapsed and/or refractory multiple myeloma regimens: A Bayesian network meta-analysis of phase 3 randomized controlled trials. Cancer. 2020 Jun 15;126(12):2791-2801. doi: 10.1002/cncr.32831. Epub 2020 Mar 10. PMID: 32154922. Cited by 5 publications

Dhakal B, D’Souza A, Hamadani M, Arce-Lara C, Schroeder K, Chhabra S, Shah NN, Gauger K, Keaton T, Pasquini M, Hari P. Phase I/II trial of bendamustine, ixazomib, and dexamethasone in relapsed/refractory multiple myeloma. Blood Cancer J. 2019 Jul 29;9(8):56. doi: 10.1038/s41408-019-0219-3. PMID: 31358733; PMCID: PMC6663939. Cited by 9 publications

Dong J, Garacci Z, Buradagunta CS, D’Souza A, Mohan M, Cunningham A, Janz S, Dhakal B, Thrift AP, Hari P. Black patients with multiple myeloma have better survival than white patients when treated equally: a matched cohort study. Blood Cancer J. 2022 Feb 24;12(2):34. doi: 10.1038/s41408-022-00633-5. PMID: 35210395; PMCID: PMC8873507. Cited by 4 publications

Johnson AK, Lorimer EL, Szabo A, Wu R, Shah NN, D’Souza A, Chhabra S, Hamadani M, Dhakal B, Hari P, Rao S, Carlson K, Williams CL, Knight JM. Rap1A, Rap1B, and β-Adrenergic Signaling in Autologous HCT: A Randomized Controlled Trial of Propranolol. Yale J Biol Med. 2022 Mar 31;95(1):45-56. PMID: 35370486; PMCID: PMC8961707. Cited by 0 publications

Knight JM, Rizzo JD, Hari P, Pasquini MC, Giles KE, D’Souza A, Logan BR, Hamadani M, Chhabra S, Dhakal B, Shah N, Sriram D, Horowitz MM, Cole SW. Propranolol inhibits molecular risk markers in HCT recipients: a phase 2 randomized controlled biomarker trial. Blood Adv. 2020 Feb 11;4(3):467-476. doi: 10.1182/bloodadvances.2019000765. PMID: 32027744; PMCID: PMC7013267. Cited by 20 publications

Pisano M, Cheng Y, Sun F, Dhakal B, D’Souza A, Chhabra S, Knight JM, Rao S, Zhan F, Hari P, Janz S. Laboratory Mice – A Driving Force in Immunopathology and Immunotherapy Studies of Human Multiple Myeloma. Front Immunol. 2021 Jun 2;12:667054. doi: 10.3389/fimmu.2021.667054. PMID: 34149703; PMCID: PMC8206561. Cited by 0 publications

Shi Y, Sun F, Cheng Y, Holmes B, Dhakal B, Gera JF, Janz S, Lichtenstein A. Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma. Mol Cancer Ther. 2022 Apr 1;21(4):502-510. doi: 10.1158/1535-7163.MCT-21-0016. PMID: 35086951; PMCID: PMC8983490. Cited by 0 publications

Williams A, Baruah D, Patel J, Szabo A, Chhabra S, Dhakal B, Hari P, Janz S, Stolley M, D’Souza A. Prevalence and significance of sarcopenia in multiple myeloma patients undergoing autologous hematopoietic cell transplantation. Bone Marrow Transplant. 2021 Jan;56(1):225-231. doi: 10.1038/s41409-020-01008-9. Epub 2020 Jul 30. PMID: 32732941; PMCID: PMC7855279. Cited by 3 publications
Obesity & Food Insecurity Ensemble: 10 Publications
Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL. Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. Hypertension. 2020 Aug;76(2):589-597. doi: 10.1161/HYPERTENSIONAHA.120.15137. Epub 2020 Jun 8. PMID: 32507042; PMCID: PMC7347451. Cited by 11 publications

Oliveira V, Kwitek AE, Sigmund CD, Morselli LL, Grobe JL. Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System. Hypertension. 2021 04;77(4):1061-1068. PMCID: PMC7990288 Cited by 5 publications

Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL. Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents. Front Physiol. 2022 Feb 25;13:855054. doi: 10.3389/fphys.2022.855054. PMID: 35283781; PMCID: PMC8914175. Cited by 5 publications

Riedl RA, Burnett CML, Pearson NA, Reho JJ, Mokadem M, Edwards RA, Kindel TL, Kirby JR, Grobe JL. Gut Microbiota Represent a Major Thermogenic Biomass. Function (Oxf). 2021;2(3):zqab019. PMCID: PMC8055641  Cited by 7 publications

Segar JL, Grobe CC, Grobe JL. Maturational changes in sodium metabolism in periviable infants. Pediatr Nephrol. 2021 Nov;36(11):3693-3698. doi: 10.1007/s00467-021-05119-3. Epub 2021 May 19. PMID: 34013388; PMCID: PMC8815317.  Cited by 1 publication

Segar JL, Balapattabi K, Reho JJ, Grobe CC, Burnett CML, Grobe JL. Quantification of body fluid compartmentalization by combined time-domain nuclear magnetic resonance and bioimpedance spectroscopy. Am J Physiol Regul Integr Comp Physiol. 2021 01 01;320(1):R44-R54. PMCID: PMC7847054 Cited by 4 publications

Segar JL, Grobe CC, Balapattabi K, Ritter ML, Reho JJ, Grobe JL. Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes. Am J Physiol Regul Integr Comp Physiol. 2021 04 01;320(4):R438-R451. PMCID: PMC8238146 Cited by 1 publication

Wagner VA, Clark KC, Carrillo-Sáenz L, Holl KA, Velez-Bermudez M, Simonsen D, Grobe JL, Wang K, Thurman A, Solberg Woods LC, Lehmler HJ, Kwitek AE. Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity. Toxicol Sci. 2021 May 27;181(2):246-261. doi: 10.1093/toxsci/kfab035. PMID: 33755180; PMCID: PMC8163043. Cited by 0 publications

Ziegler AA, Grobe CC, Reho JJ, Jensen ES, Thulin JD, Segar JL, Grobe JL. Short-term Housing in Metabolic Caging on Measures of Energy and Fluid Balance in Male C57BL/6J Mice ( Mus musculus). J Am Assoc Lab Anim Sci. 2022 Mar 1;61(2):132-139. doi: 10.30802/AALAS-JAALAS-21-000087. Epub 2022 Jan 7. PMID: 34996529; PMCID: PMC8956215. Cited by 2 publications

Wagner Valerie A., Deng Guorui, Claflin Kristin E., Ritter McKenzie L., Cui Huxing, Nakagawa Pablo, Sigmund Curt D., Morselli Lisa L., Grobe Justin L., Kwitek Anne E. Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension. Frontiers in Cellular Neuroscience.

Funded May 1, 2021

Non-Invasive Biomarkers of Acute Profibrotic Conditions and Chronic Stress Diseases: A Proteostasis Index: 1 Publication
Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O’Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ. Collagen-Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections. J Am Heart Assoc. 2023 Feb 21;12(4):e027990. doi: 10.1161/JAHA.122.027990. Epub 2023 Feb 15. PMID: 36789856. † 
Pediatric Collaborative for Resilience and Emotional Wellness Science (CREWS): 2 Publications

Lim PS, Olen A, Carballido JK, LiaBraaten BM, Sinnen SR, Balistreri KA, Tager JB, Rothschild CB, Scanlon MC, Davies WH, Nordness K. “We need a little help”: a qualitative study on distress and coping among pediatric medical interpreters. J Hosp Manag Heal Policy. 2022;1:0-0. doi:10.21037/jhmhp-22-23 

Olen, Amy, Paulina S. Lim, Kathryn A. Balistreri, W. Hobart Davies, Matthew C. Scanlon & Charles B. Rothschild. 2022. “It’s just another added layer of difficulty’: Language access equity and inclusion in pediatric interpreted medical encounters – Provider and interpreter perspectives.” In “Language Policies for Social Justice,” edited by aChristopher D. Mellinger & Esther Monzó-Nebot. Special issue, Just. Journal of Language Rights & Minorities, Revista de Drets Lingüístics i Minories 1 (1-2): 101-135. 

Funded June 1, 2021

Cardio-Oncology Risk Prediction AI Ensemble: 2 Publications
Brown SA, Sparapani R, Osinski K, Zhang J, Blessing J, Cheng F, Hamid A, Berman G, Lee K, BagheriMohamadiPour M, Lal JC, Kothari AN, Caraballo P, Noseworthy P, Johnson RH, Hansen K, Sun LY, Crotty B, Cheng YC, Olson J; Cardio-Oncology Artificial Intelligence Informatics & Precision (CAIP) Research Team Investigators. Establishing an interdisciplinary research team for cardio-oncology artificial intelligence informatics precision and health equity. Am Heart J Plus. 2022 Jan;13:100094. doi: 10.1016/j.ahjo.2022.100094. Epub 2022 Feb 5. PMID: 35434676; PMCID: PMC9012235. Cited by 1 publication

Brown SA, Chung BY, Doshi K, Hamid A, Pederson E, Maddula R, Hanna A, et al; Cardio-Oncology Artificial Intelligence Informatics and Precision Equity (CAIPE) Research Team Investigators. Patient similarity and other artificial intelligence machine learning algorithms in clinical decision aid for shared decision-making in the Prevention of Cardiovascular Toxicity (PACT): a feasibility trial design. Cardiooncology. 2023 Jan 23;9(1):7. doi: 10.1186/s40959-022-00151-0. PMID: 36691060; PMCID: PMC9869606. †
Persistent Effects of Covid-19 on Physical Function: 1 Publication
Cain MT, Smith NJ, Barash M, Simpson P, Durham LA 3rd, Makker H, Roberts C, Falcucci O, Wang D, Walker R, Ahmed G, Brown SA, Nanchal RS, Joyce DL. Extracorporeal Membrane Oxygenation with Right Ventricular Assist Device for COVID-19 ARDS. J Surg Res. 2021 Aug;264:81-89. doi: 10.1016/j.jss.2021.03.017. Epub 2021 Mar 18. PMID: 33789179; PMCID: PMC7969863. †
Preconception to Toddler Study Ensemble: 4 Publications
McDonnell S, Yan K, Kim UO, Flynn KE, Liegl MN, Leuthner SR, McIntosh JJ, Basir MA. Information Order for Periviable Counseling: Does It Make a Difference? J Pediatr. 2021 Aug;235:100-106.e1. doi: 10.1016/j.jpeds.2021.03.058. Epub 2021 Apr 1. PMID: 33811868; PMCID: PMC8316277. Cited by 0 publications

Segar JL, Grobe CC, Grobe JL. Maturational changes in sodium metabolism in periviable infants. Pediatr Nephrol. 2021 Nov;36(11):3693-3698. doi: 10.1007/s00467-021-05119-3. Epub 2021 May 19. PMID: 34013388. Cited by 1 publication

Segar JL, Grobe CC, Balapattabi K, Ritter ML, Reho JJ, Grobe JL. Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes. Am J Physiol Regul Integr Comp Physiol. 2021 Apr 1;320(4):R438-R451. PMC8238146 Cited by 1 publication

Segar JL, Balapattabi K, Reho JJ, Grobe CC, Burnett CML, Grobe JL. Quantification of body fluid compartmentalization by combined time-domain nuclear magnetic resonance and bioimpedance spectroscopy. Am J Physiol Regul Integr Comp Physiol. 2021 Jan 1;320(1):R44-R54. PMC7847054  Cited by 4 publications