FORM COMPLETION TIPS
Receiving IRB approval does not guarantee Honest Broker approval. If you might use identified data from the CRDW for your project, please make sure your eBridge SmartForm is updated to include these Honest Broker checkpoints.
Existing protocols should be reviewed to ensure all IRB checkpoints below are covered. In some cases, the team must submit a protocol amendment to include additional elements and/or language. To request a proactive protocol review, please contact CRDW@mcw.edu.
The Honest Broker Data Dictionary contains detailed definitions for all our extractable tables.
2 MBCTSI Honest Broker Data Dictionary
The i2b2 cohort query and Honest Broker extract tools include the following data domains from which researchers can select criteria for cohort characterization and/or extract tables for analysis/recruitment.
The TriNetX cohort query and analysis tool includes the following domains. Patient lists can be exported from TriNetX and used in Honest Broker to extract datasets.
Read/Download Language to Include in IRB Applications
Investigators must cite both AHW and Medical College of Wisconsin CTSA Grant UL1TR001436.
This includes use of the self service cohort discovery tool, data consultations, clinical queries, and data extraction services made by our team.
“This project is funded in part by the Advancing a Healthier Wisconsin endowment at the Medical College of Wisconsin.”
Please acknowledge the Medical College of Wisconsin CTSA Grant UL1TR001436. All publications must comply with NIH Public Access Policy.
Researchers other than K Scholars (KL2) – Please cite Grant UL1TR001436, as follows:
“This publication [or project] was supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant Number UL1TR001436. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.”
K Scholars (KL2) – Please cite Grant KL2TR001438, as follows:
“This publication [or project] was supported by the National Center for Research Resources, the National Center for Advancing Translational Sciences, and the Office of the Director, National Institutes of Health, through Grant Number KL2TR001438. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.”
Please see our citation information for details.
Inquiries and consultations on new research projects are offered free of charge to CTSI community researchers. In general, Biomedical Informatics will provide one hour of labor for a project before we need to discuss setting up a payment plan.
When additional payment is required, we will execute a Statement of Work and Letter of Agreement with mutually agreeable terms. The PI will be responsible for covering a standard billing rate on an hourly basis for the time spent working on your project. Projects with larger scope or longer terms may be “contracted” via a Funding Proposal.
In projects where Biomedical Informatics expertise is required, we may engage in a collaborative partnership leading to co-authorship on related publications. In such a collaboration, and particularly where the work is of shared interest, we may be able to extend a cost-sharing of services.
Each project receives 1 hour of complimentary training and 1 hour of complimentary support. Biomedical Informatics support beyond the complimentary 2 hours, as outlined above, is considered out of scope and may affect your data delivery timeline and/or budget.
Contracted project support is billed hourly at a rate of $100 per hour. No project work can begin until a signed Letter of Agreement and Statement of Work has been fully executed. To achieve this state, the Biomedical Informatics team must receive a well-formed service request including but not limited to:
No work on scope changes will be done before both parties agree on cost and timeline changes and are client authorized with approval of a written change order.
Fees last updated June 30, 2017
Do I need an IRB protocol to use the CRDW query tools?
No, the CRDW query tools ONLY contain fully de-identified data
Do I need an IRB protocol to use external data sources for my project?
Maybe. Please contact irboffice@mcw.edu to get this question answered
Currently, the use of SEER data does require teams to write an IRB protocol
Do I need an IRB protocol to extract identified data (real MRNs/real dates) from Honest Broker?
Yes, IRB approval is required and certain eBridge SmartForm sections must be populated. See requirements above!
Do I need an IRB protocol to publish findings for a project that uses CRDW data?
Maybe. Please contact irboffice@mcw.edu to get this question answered
Do I need an IRB protocol for a QI project that uses identified CRDW data?
You might… approval is required from the IRB or a designated QI authority in your department. If your department/division/center does not have a QA/QI review process, contact Froedtert’s OCRICC team or MCW’s IRB for advice on next steps.
This self-service tool brings the power of a computational environment to researchers with advanced data science skills, allowing them to independently query and analyze encrypted Honest Broker tables directly.
This self-service research data platform is more than just a cohort discovery tool. TriNetX provides a variety of analytics features to complement their cohort development toolset. As well, teams can run queries and analyze data on larger research networks within the US and worldwide.
The Center for Biomedical Informatics offers an instance of REDCap to support clinical research. We strongly encourage researchers to consult with a biostatistician from their department/division or the CTSI BERD team before beginning data analysis.
NIH Funding Acknowledgment: Important Reminder – Please acknowledge the NIH when publishing papers, patents, projects, and presentations resulting from the use of CTSI resources by including the NIH Funding Acknowledgement.