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2024 Translational Research and Translational Science “Dual Focus” Ensemble Awards

Translational Research and Translational Science “Dual-Focus” Ensemble Awards 2024

The Clinical & Translational Science Institute of Southeast Wisconsin (CTSI) will advance the field of translational science by funding two Translational Research AND Translational Science “Dual-Focus” Research Ensembles, $50,000 each.

The research activities and products of these Ensembles must be two-fold:

  1. Translational Research ─ Use clinical and translational research and appropriate expertise to create solutions that address an important unmet patient medical need.
  2. Translational Science ─ Identify underlying obstacles and roadblocks that slow the translational process and use appropriate research activities and expertise to develop and implement solutions that remove these roadblocks and improve translational efficiency.

Ensembles may focus their clinical and translational research on any disease and may address any underlying translational science barriers.

Letter of Intent deadline was December 11th, 2023. LOI submission is now closed. 

Translational research, as we are familiar with, is defined as the endeavor to traverse steps of the translational process for a particular target or disease. Whereas translational science is defined as the field of investigation focused on understanding the scientific and operational principles underlying each step of the translational process. The discovery of the scientific, mechanistic, and operational principles of the intervention development and dissemination process, provides the scientific foundation for improving translational efficiency and accelerating interventions that improve health.

Translational Science: “Sometimes the System or Process is Sick”

Examples of translational science research targets:  

  • Impediments that prevent:
    • translation of basic science discoveries into first-in-human investigation
    • collaboration between basic scientists and clinician scientists
    • meaningful participation and collaboration of community members in the research process
    • patient data de-identification
    • clinic uptake/adoption of new process
    • phase-out of outdated clinical processes
  • Implementation of novel research methods such as decentralized trials, platform trials or n-of-1 trials
  • Connecting parallel research activities/strategies to increase efficiency and innovation
  • Increasing inpatient clinical trial recruitment
  • Implementing efficiencies for patient recruitment, e.g., automatic opt-in, or E-consent process
  • Standardizing education and training for clinical research
  • Accelerating the patent or commercialization process

Team Members

The Translational Research AND Translational Science Research Ensemble will integrate various experts and stakeholders to address a specific unmet patient medical need(s) and translational science barrier(s). The composition of a CTSI Ensemble is multidisciplinary, and may include basic, clinical, translational, and community health investigators, as well as clinicians, patient representatives, advocacy groups, community stakeholders, and health system experts.

Important: The addition of patients and community members adds critical perspectives that help guide the team’s direction. Members of the team can also provide context-driven feedback after the Ensemble completes a research project.


All investigators and translational research accelerators at CTSI partner institutions are eligible to participate in this funding opportunity. Partner institutions include Medical College of Wisconsin, University of Wisconsin-Milwaukee, Marquette University, Milwaukee School of Engineering, Children’s Wisconsin, Versiti Blood Center, Froedtert Hospital, and Zablocki Veterans Affairs Medical Center. 

Important Dates

  • October 30, 2023 – RFA Release
  • November 6, 2023 – Begin Consultation Sessions
  • November 14, 2023: – Town Hall RFA Discussion (Virtual) at Noon.* View the Recording (Passcode: bB?ee+61)
  • November 15, 2023: – Town Hall RFA Discussion (Virtual) at 5pm.*
  • December 11, 2023: – Letter of Intent (Required)
  • By January 12, 2024: – Begin Pre-Ensemble meetings (Required) with CTSI Project Manager and applicant team for team building, development of shared goals, and proposal development.
  • March 25, 2024 – Proposal Deadline; Allows ~5 months for Pre-Ensemble meetings and proposal development
  • April 22, 2024 – Start Date

*Video recording for those that cannot attend


656 KBView the full Request for Applications


Please contact David Zimmerman (dzimmerman@mcw.edu) with any questions.

NIH Funding Acknowledgment: Important Reminder – Please acknowledge the NIH when publishing papers, patents, projects, and presentations resulting from the use of CTSI resources by including the NIH Funding Acknowledgement.


Children's Hospital of WisconsinMarquette UniversityMSOEUWMVersitiVA Medical Center