John & Jeanne Byrnes CTSI Award

John & Jeanne Byrnes CTSI Award

The goal of this RFA is to support collaborative research in the life sciences requiring modeling, simulation and visualization techniques. These are projects seeking solutions to large-scale (systems-level) problems in coupling clinical and translational medicine; problems that typically require the use of high performance computing (HPC) systems and services.


Not currently open for applications

Awards under this RFA seek to stimulate interactive patient centered research among clinical scientists, social scientists, biostatisticians, informatics specialists, geneticist, systems scientists, bioengineers, and other members of health care delivery community. Funds will be provided to support investigations into new and promising mechanisms for the delivery of effective patient care through tighter coupling of basic science and clinical research.

Research Topics of Interest

Research topics of interest include, but are not limited to:

  • Modeling of efficient and traceable exchanges (protocols) supporting the efficient, real-time, bidirectional exchange of information between research scientists and clinicians;
  • Projects that simulate new diagnostic and/or therapeutic modalities associated with specific diseases;
  • Genetics-oriented projects that model clinical practices that incorporate predictive criteria for disease outcome, response to therapy and tumor dissemination; and
  • Innovative approaches to modeling and simulation of efficient healthcare delivery processes that promise to lead to error-free hospitals.

RFA for 2012 Funding Cycle

There is an expectation that studies supported by this RFA will generate subsequent extramural funding from NIH, NSF, and/or other similar sources.

Key Dates

Key Dates

  • Letters of Intent (mandatory) Deadline: August 1, 2011
  • eBridge Submission Deadline: August 25, 2011
  • Application Submission Deadline: September 1, 2011
  • CTSI Peer-Review: November, 2011
  • CTSI Executive Committee Review: January/February, 2012
  • Funds Available for Awarded Projects: April 1, 2012



This RFA supports a collaborative effort between the Clinical and Translational Science Institute (CTSI) and the Milwaukee Institute (MKEI). The CTSI is designed to advocate, facilitate and foster the continuum of research from bench to bedside, and from bedside to community practices and to our citizens. It is the goal of the CTSI to diminish the barriers between institutions and disciplines while encouraging novel approaches to solving complex health related problems facing clinicians. It supports translational research that focuses on discovery regarding the application of scientific findings into the real-world setting.

The mission of MKEI is to assist SE Wisconsin to better compete in a competitive global economy, an economy that is increasingly driven and enabled by high-speed computational systems and services. The Milwaukee Institute provides “collaboration services” that allow organizations, their people and processes to interact in a semi-structured manner for the purpose of creating and exercising computational models of value creation. Such inter-institutional and inter-disciplinary alliances create “virtual organizations.” Achieving broad scientific aims (“grand challenges”) in medical science requires collaboration among basic and clinical scientists, social scientists, ethicists, biostatisticians, engineers, organizational theorists, and innovators in the broad area of medical informatics (information technology).

Ultimately, a goal of cooperation between CTSI and MKEI is to create computational tools and new clinical-translational applications that support improved, real-time, bidirectional information flows between biomedical research enterprises and the communities they serve – to ultimately improve health outcomes.



Principal Investigators

Principal investigators may be from any of the CTSI partnering institutions, which include: Medical College of Wisconsin, Marquette University, Milwaukee School of Engineering, University of Wisconsin – Milwaukee, BloodCenter of Wisconsin, Zablocki VA Medical Center, Froedtert Hospital and Children’s Hospital of Wisconsin.

Applications should be multi-institutional and multi-disciplinary:

  • Any Principal Investigator may submit only one application in response to this RFA;
  • Support of faculty salaries are permitted up to a maximum of 15% effort (Utilizing NIH maximum salary limits when appropriate);
  • No “indirect costs” may be charged for any funding;
  • Principal Investigators may receive CTSI awards for successive, but not concurrent or overlapping, proposals;
  • Funding under this RFA cannot be used as “bridge funding” for lapsed grants from any extramural source and is intended for new projects;
  • All personnel must be identified prior to the start date to replace any “to be named” positions proposed in the application;
  • No funds may be requested for purchase of laboratory, computing or clinical equipment;
  • CTSI funds cannot be used to supplant funds or resources that are available from other sources. Use of CTSI funds to supplement other financial resources is permitted with clear justification. Matching funding and opportunities to leverage CTSI funds to obtain other sources of financial support are specifically encouraged;
  • Investigators are encouraged to consult with their institution’s statistician/biostatistician and IT personnel during proposal development. The CTSI offers free biostatistics consulting services and MKEI offers free modeling services;
  • Investigators are encouraged to utilize, if appropriate, available Translational Research Unit (TRU) services;
  • Investigators are encouraged to submit IRB applications when they submit their proposals to the CTSI to minimize delays in initiating funded applications; and
  • Principal Investigators will be expected to comply with reporting requirements as a condition of receipt of funds including acknowledgement of CTSI support in all publications resulting from this award.

How to Apply

How to Apply

Step 1: Form a Collaborative Team

Multi-Institutional collaborations

If investigators are interested in forming new collaborative relationships, they are encouraged to contact the Clinical and Translational Science Research Support Office (CTRSO). The directors of the CTRSO can assist with identifying potential multi-disciplinary and multi-institutional collaborators for these projects. You may also want to visit the Faculty Collaboration Database to locate subject experts, potential collaborators and mentors.

Step 2: Submit a Letter of Intent

A Letter of Intent (not to exceed two pages) is mandatory prior to the submission of the application for the purpose of identifying reviewers with the appropriate expertise for your proposal. Letters of Intent should be submitted electronically through the CTSI website.

Please include the following in your letter:

  • Title
  • PI
  • Key Personnel
  • Brief description of the project as it relates to the mission of the CTSI
  • 2-3 suggested reviewers
Step 3: Create your proposal

Please use the following format.

  1. Abstract
    The abstract of the proposed research project should not exceed 500 words.
  2. Budget & Budget Justification
    Budget and budget justification for supplies and personnel.
    Download the Budget Form
  3. NIH PHS 398
    Use the NIH (PHS 398) format (using 0.5 inch margins and 11 point Arial font) starting with Specific Aims – one page limit.
  4. Research Strategy
    (A. Significance, B. Innovation and C. Approach) with a six page limit. A section should also be included in which the investigator describes the translational aspects of the proposal (D. Translational Aspects). Literature citations should be listed at the end of the proposal but will not be included as part of the six page limit.
  5. Descriptions of how the CTSI’s infrastructure will provide support for your project
    Proposals should include descriptions of how CTSI infrastructure will provide regulatory support, specialized core laboratory support, assistance with data collection and analysis or report preparation. Biostatistical consultation is highly recommended as is use of the TRUs.
    Learn More about the TRUs→
  6. Research Impact Statement, Project timeline and Future Plans
    This required section should follow the proposal and not exceed one page (not included in page limit). Describe the goal of the proposed project and the long range objectives, provide a timeline for the project and provide a future plan that specifically describes how this grant will lead to future grant funding.
  7. NIH Biosketches
    Biographical sketches of the PI and key personnel (limit 4 pages per individual). Follow the new NIH biosketch format (parts A-D):
  8. Letters of Collaboration
    Please include statements of collaboration from each of the co-investigators.
Step 4: Submit the application to your institution

MCW Investigators

For MCW investigators, an additional application must also be submitted through eBridge and must be received by the Office of Grants & Contracts (GCO) no later than 5 business days before the CTSI deadline (August 25,2011).

MU Investigators

For MU investigators, the application must be registered via the routine Proposal Registration process with the Office of Research and Sponsored Programs prior to submission to CTSI. This process is required for proposals in which MU is the prime applicant and those for which MU is the collaborating applicant receiving funds. Remember that Marquette requires that a signed institutional letter of intent is in hand from all sub-awardees or collaborating institutions who will be receiving funds (i.e. MCW, UWM, MSOE, etc.) from a grant in which MU is the prime applicant prior to submission. Please contact an ORSP staff member early in your application preparation process as we can assist with forms, budget formulation, proofreading, securing sub-award letters of intent, etc.

UWM Investigators

For UWM investigators, full applications must be routed using the WISPER system and approved by the Office of Sponsored Programs prior to submission to CTSI. Letters of Intent do not require a WISPER record.

MSOE Investigators

For MSOE investigators, please contact Tom Bray, Dean of Applied Research, 277-7416 or email.

Step 5: Submit your application to the CTSI

Investigators who have submitted letters of intent will be granted access to the Application Form on August 2, 2011. Applications must be submitted electronically to the CTSI office by midnight September 1, 2011.

Review Process

Review process

The Pilot and Collaborative Clinical and Translational Research Program (PCCTRP) Committee, in association with Dr. Jay Bayne, PhD, Executive Director of MKEI, and appropriate ad hoc reviewers serving at the request of the committee, will review all applications.

This committee is comprised of 10 members including the Director of the PCCTRP (Allen W. Cowley, Jr., PhD.), the Co-Director (Larry Fennigkoh, Ph.D., MSOE), three members from the MCW campus partner institutions (Drs. Ann Nattinger, Elizabeth Jacobs, and John Routes), one additional member from MSOE (Dr. John Gassert), two members from UWM (Drs. Sally Lundeen and Ann Greer) and two members from Marquette University (Drs. Brian Schmit and Lawrence Pan).

Ad hoc reviewers will be added as necessary to provide expertise needed based on the focus of the applications submitted. The recommendations of the review panel will be made to the CTSI Executive Committee for strategic/programmatic considerations and approval. This process will ensure equitable representation of all of the partner institutions within the CTSI.

Conflict of Interest: Investigators that are in the same division or have worked or published together in the last three years, will not be allowed to review one another’s application and must recuse themselves from discussion.

NIH Funding Acknowledgment: Important Reminder – Please acknowledge the NIH when publishing papers, patents, projects, and presentations resulting from the use of CTSI resources by including the NIH Funding Acknowledgement.

Zablocki VA Medical CenterFroedtert HospitalMedical College of Wisconsin Childrens Hospital of WisconsinBloodCenter of WisconsinUniversity of Wisconsin - MilwaukeeMarquette UniversityMilwaukee School of Engineering