The goal of this RFA is to support collaborative research in the life sciences requiring modeling, simulation and visualization techniques. These are projects seeking solutions to large-scale (systems-level) problems in coupling clinical and translational medicine; problems that typically require the use of high performance computing (HPC) systems and services.
Not currently open for applications
Awards under this RFA seek to stimulate interactive patient centered research among clinical scientists, social scientists, biostatisticians, informatics specialists, geneticist, systems scientists, bioengineers, and other members of health care delivery community. Funds will be provided to support investigations into new and promising mechanisms for the delivery of effective patient care through tighter coupling of basic science and clinical research.
Research topics of interest include, but are not limited to:
There is an expectation that studies supported by this RFA will generate subsequent extramural funding from NIH, NSF, and/or other similar sources.
This RFA supports a collaborative effort between the Clinical and Translational Science Institute (CTSI) and the Milwaukee Institute (MKEI). The CTSI is designed to advocate, facilitate and foster the continuum of research from bench to bedside, and from bedside to community practices and to our citizens. It is the goal of the CTSI to diminish the barriers between institutions and disciplines while encouraging novel approaches to solving complex health related problems facing clinicians. It supports translational research that focuses on discovery regarding the application of scientific findings into the real-world setting.
The mission of MKEI is to assist SE Wisconsin to better compete in a competitive global economy, an economy that is increasingly driven and enabled by high-speed computational systems and services. The Milwaukee Institute provides “collaboration services” that allow organizations, their people and processes to interact in a semi-structured manner for the purpose of creating and exercising computational models of value creation. Such inter-institutional and inter-disciplinary alliances create “virtual organizations.” Achieving broad scientific aims (“grand challenges”) in medical science requires collaboration among basic and clinical scientists, social scientists, ethicists, biostatisticians, engineers, organizational theorists, and innovators in the broad area of medical informatics (information technology).
Ultimately, a goal of cooperation between CTSI and MKEI is to create computational tools and new clinical-translational applications that support improved, real-time, bidirectional information flows between biomedical research enterprises and the communities they serve – to ultimately improve health outcomes.
Principal investigators may be from any of the CTSI partnering institutions, which include: Medical College of Wisconsin, Marquette University, Milwaukee School of Engineering, University of Wisconsin – Milwaukee, BloodCenter of Wisconsin, Zablocki VA Medical Center, Froedtert Hospital and Children’s Hospital of Wisconsin.
If investigators are interested in forming new collaborative relationships, they are encouraged to contact the Clinical and Translational Science Research Support Office (CTRSO). The directors of the CTRSO can assist with identifying potential multi-disciplinary and multi-institutional collaborators for these projects. You may also want to visit the Faculty Collaboration Database to locate subject experts, potential collaborators and mentors.
A Letter of Intent (not to exceed two pages) is mandatory prior to the submission of the application for the purpose of identifying reviewers with the appropriate expertise for your proposal. Letters of Intent should be submitted electronically through the CTSI website.
Please include the following in your letter:
Please use the following format.
For MCW investigators, an additional application must also be submitted through eBridge and must be received by the Office of Grants & Contracts (GCO) no later than 5 business days before the CTSI deadline (August 25,2011).
For MU investigators, the application must be registered via the routine Proposal Registration process with the Office of Research and Sponsored Programs prior to submission to CTSI. This process is required for proposals in which MU is the prime applicant and those for which MU is the collaborating applicant receiving funds. Remember that Marquette requires that a signed institutional letter of intent is in hand from all sub-awardees or collaborating institutions who will be receiving funds (i.e. MCW, UWM, MSOE, etc.) from a grant in which MU is the prime applicant prior to submission. Please contact an ORSP staff member early in your application preparation process as we can assist with forms, budget formulation, proofreading, securing sub-award letters of intent, etc.
For UWM investigators, full applications must be routed using the WISPER system and approved by the Office of Sponsored Programs prior to submission to CTSI. Letters of Intent do not require a WISPER record.
For MSOE investigators, please contact Tom Bray, Dean of Applied Research, 277-7416 or email.
Investigators who have submitted letters of intent will be granted access to the Application Form on August 2, 2011. Applications must be submitted electronically to the CTSI office by midnight September 1, 2011.
The Pilot and Collaborative Clinical and Translational Research Program (PCCTRP) Committee, in association with Dr. Jay Bayne, PhD, Executive Director of MKEI, and appropriate ad hoc reviewers serving at the request of the committee, will review all applications.
This committee is comprised of 10 members including the Director of the PCCTRP (Allen W. Cowley, Jr., PhD.), the Co-Director (Larry Fennigkoh, Ph.D., MSOE), three members from the MCW campus partner institutions (Drs. Ann Nattinger, Elizabeth Jacobs, and John Routes), one additional member from MSOE (Dr. John Gassert), two members from UWM (Drs. Sally Lundeen and Ann Greer) and two members from Marquette University (Drs. Brian Schmit and Lawrence Pan).
Ad hoc reviewers will be added as necessary to provide expertise needed based on the focus of the applications submitted. The recommendations of the review panel will be made to the CTSI Executive Committee for strategic/programmatic considerations and approval. This process will ensure equitable representation of all of the partner institutions within the CTSI.