Froedtert Hospital
| Location | Location | Name | Description | Link | CTSI Core/Service | Free Core Access |
|---|---|---|---|---|---|---|
| Froedtert Hospital |  | ADULT ECHOCARDIOGRAPHY CORE LABORATORY More Info | The Adult Echocardiography Core provides high-quality cardiovascular imaging along with quantitative and qualitative imaging analysis for cardiovascular clinical trials and investigator initiated protocols. The Core faculty and staff offers expertise, materials, consultation, performs scanning and analysis on a fee for service basis. The Core serves Investigators affiliated with the Medical College of Wisconsin. We provide consultation on image acquisition and analysis based upon American Society of Echocardiography (ASE) recommendations for the performance and evaluation of a comprehensive transthoracic echocardiogram, use of echocardiography in clinical trials and employ the ASE Standards for Echocardiography Core Laboratories. Successful and timely scanning and data analysis requires a concerted, collaborative effort of the Investigator and the Core staff in all stages of the study. Investigators planning on utilizing Core services are therefore encouraged to contact the staff early in the planning stages of the study. | View | Yes | No |
| Froedtert Hospital | | ADULT TRANSLATIONAL RESEARCH UNIT More Info | Scientists at the Medical College of Wisconsin and at any of the CTSI partner institutions who have an approved protocol can utilize the TRU facilities. We provide support services for a diverse array of research studies, which involve pulmonary, cardiovascular, chronic kidney, neurological (Alzheimer’s), metabolic, sickle cell, genetics and rare diseases to include a few. The Adult TRU is located in close proximity to the main entrance of the Pavilion building of Froedtert Hospital. The unit is able to provide a wide array of basic clinical research services including nursing support, dedicated nursing time, use of exam rooms and equipment, laboratory sample preparation and consultations. Special arrangements can be made for studies requiring TRU support in a hospital setting. SERVICES - The A-TRU team is available to assist with a variety of services including : Research nursing support and dedicated nursing time, Laboratory sample preparation and processing, Assistance with inpatient studies, Glucose Analysis, and Noninvasive BP Monitoring. | View | Yes | No |
| Froedtert Hospital | | BIONUTRITION AND BODY COMPOSITION LAB More Info | The Clinical and Translational Science Institute’s Bionutrition and Body Composition Lab is based out of the Adult Translational Research Unit (ATRU) and provides services to researchers from all CTSI affiliated institutions and community organizations. Researchers and community health initiatives find that body composition and nutrition play an important role in promoting health and the treatment of disease. Even if nutrition and body composition are not a primary focus, an estimate on body composition and nutrient intake is often desired due to the influence both have on human physiology and public health determinates. OVERVIEW The CTSI Bionutritionist assists with planning, developing, implementing, and evaluating the nutrition and body composition components of research protocols and community programs. The ATRU houses a metabolic kitchen dedicated to providing general or protocol specific meals. It also has a body composition lab where whole body DXA scans, anthropometric measurements, bioelectrical impedance analysis, and energy assessment take place. | View | Yes | No |
| Froedtert Hospital | | CLINICAL AND TRANSLATIONAL RESEARCH CORE LAB (CTRL) HISTOLOGY More Info | The Clinical and Translational Research Core Lab (CTRL) combines two major components in one lab: histopathology and molecular pathology. The CTRL provides basic histopathology, research immunohistochemistry, tissue microarray, laser capture microdissection, and molecular biology services to researchers at the Medical College of Wisconsin and within the surrounding academic community. Histopathology services include: tissue processing, embedding, and cutting both paraffin-embedded and frozen tissue. The CTRL performs standard stains, immunohistochemistry, antibody workup, and in situ hybridization. Tissue microarrays are constructed using a Veridiam VT110C. Digital imaging includes the ACIS III (DAKO), Visiopharm, and Nanozoomer (Hamamatsu). Specialized software is available to image and analyze tissue microarrays, and to manage and store array data. The histology activities are performed by an HT (ASCP) certified histology technologist with twenty years of histology experience. Histology Core Lab Services Gross description and analysis of tissue specimens Gross dissection of specimens (MOPEC) Slide printer with barcoding (ThermoSlidemate) Cassette printer with barcoding (ThermoPrintmate) Tissue processing (Sakura VIP6) Tissue paraffin embedding (Sakura TEK6) Tissue sectioning to make slides (Thermo HM 355S) Frozen sections (Thermo HM 525) Slide staining (Leica Autostainer) Immunohistochemical analysis (DAKO Autostainer XL) Immunofluorescence (Olympus BX61) Special staining Tissue microarray construction (Veridiam) Quantitative image analysis (DAKO ACIS III) Laser capture microscopy (Arcturus) Pathological interpretation Tumor Identification Equipment/Software MOPEC Gross dissection of specimens ThermoSlidemate slide printer with barcoding ThermoPrintmate cassette printer with barcoding Sakura VIP6 tissue processing Sakura TEK6 tissue paraffin embedding Thermo HM 355S tissue sectioning to make slides Thermo HM 525 frozen sections Leica Autostainer slide staining DAKO Autostainer XL immunohistochemical analysis Olympus BX61 immunofluorescence Veridiam Tissue microarray construction DAKO ACIS III quantitative image analysis Arcturus laser capture microscopy Leica Cytovision Software for FISH Analysis | View | No | No |
| Froedtert Hospital | | CLINICAL AND TRANSLATIONAL RESEARCH CORE LAB (CTRL) MOLECULAR SERVICES More Info | The Clinical and Translational Research Core Lab (CTRL) combines two major components in one lab: histopathology and molecular pathology. The CTRL provides basic histopathology, research immunohistochemistry, tissue microarray, laser capture microdissection, and molecular biology services to researchers at the Medical College of Wisconsin and within the surrounding academic community. Molecular Diagnostic Services The CTRL offers clinical molecular diagnostic testing for routine patient care, clinical trials, and research. Molecular services include: nucleic acid extraction from tissues (fresh, frozen, blood, formalin fixed paraffin embedded), nucleic acid quantification, PCR, real time PCR, quantitative PCR, dideoxy sequencing, massively parallel sequencing, capillary electrophoresis, gel electrophoresis, digital electrophoresis, and microarray analysis (Agilent format). Molecular Core Lab Services Nucleic acid purification (Qiagen BioRobot EZ1) Nucleic acid quantification (Nanodrop; Qbit) Agilent Bioanalyzer PCR (ABI Veriti) Real time PCR (Lightcycler; ABI 7500) Reverse transcriptase PCR Quantitative PCR (Lightcycler; ABI 7500) Dideoxy sequencing (ABI 3500) Ion Torrent PGM DNA fragment analysis (ABI 3500) DNA microarray analysis (Innopsys Scanner) Ozone-free working environment (SciGene) Gene expression microarray analysis (Innopsys) Gel electrophoresis (Agarose, acrylamide) Fluorescence in situ hybridization (FISH) Equipment/Software Qiagen BioRobot EZ1 nucleic acid purification Nanodrop; Qbit nucleic acid quantification Agilent Bioanalyzer ABI Veriti PCR Lightcycler2.0 ABI 3500 DNA fragment analysis and dideoxy sequencing Ion Torrent PGM Innopsys Scanner DNA/RNA microarray analysis SciGene ozone-free working environment Agarose, acrylamide gel electrophoresis ABI 7500 Quantitative PCR | View | No | No |
| Froedtert Hospital | | i2b2 COHORT DISCOVERY TOOL More Info | The i2b2 Cohort Discovery Tool provides an easy to use, self-service way for the Medical College of Wisconsin researchers to query the i2b2 Clinical & Translational Research Informatics Data Warehouse (CTRI-CRDW) to answer the question “Does the i2b2 CTRI-CRDW contain a cohort of patients with these characteristics?”. Search criteria can include patient demographics, ICD coded diagnoses, ICD and CPT coded procedures, laboratory test results, inpatient pharmacy orders and text within clinical documents, including surgical pathology reports and radiology reports. In response to a query, the Cohort Discovery Tool returns the approximate number of patients matching the search criteria. No patient identifiers or clinical data is revealed. Researchers can store their cohort searches online and later meet with staff from the Medical College of Wisconsin Clinical & Translational Research Informatics team to discuss how they might review and extract detailed clinical data on patient cohorts for research purposes. Release of data from the i2b2 CTRI-CRDW for research purposes requires Medical College of Wisconsin IRB approval. | View | Yes | No |
| Froedtert Hospital | | IRB NAVIGATOR More Info | Investigators that have received an award from CTSI and require IRB approval for their study can enjoy the assistance of personalized IRB navigation: guidance through eBridge prior to submission, track protocol’s progress as it moves through the review process and track and troubleshoot delays to promote successful completion. The IRB Navigator is a research service offered to investigators who have received an award from CTSI and require IRB approval for their study. The IRB Navigator provides investigators with assistance through the approval process and helps to ensure the process runs smoothly. Prior to, during and after the application is submitted through eBridge, the IRB Navigator can monitor it and troubleshoot to help advance the application to a successful completion. If there are areas that need further explanation prior to the application going to the IRB committee, the IRB Navigator acts as a liaison between the investigator and the IRB Coordinator to assist in providing clarification so the appropriate information is presented to reviewers and committee chair. After a study is approved, the IRB Navigator can assist with amendments and potentially reportable events. | View | Yes | No |
| Froedtert Hospital | | LYMPHOCYTE PROPAGATION LABORATORY (LPL) More Info | The Medical College of Wisconsin Cancer Center Lymphocyte Propagation Laboratory (LPL) is part of the Blood and Marrow Transplantation Program of the Medical College of Wisconsin. This laboratory provides cellular therapy product processing for human clinical trials. The laboratory primarily focuses on cellular therapy to improve the outcome of blood and marrow transplantation and the use of immunotherapy to combat human cancer. The laboratory is CAP accredited, CLIA certified and is accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) for the testing and processing activities that are performed. Services include: Consultation during early and mid-phase development Identification of acceptable reagent and material sources Assistance to prepare for FDA pre-IND meeting Scale-up and/or transition to clinical grade product Assist with writing of the chemistry, manufacturing, and controls (CMC) section of IND Application Preparation of FDA compliant SOPs, workforms/batch records, and reports for product preparation and testing Assist with the selection and validation of assays to ensure product safety, purity, and potency during phase I and II. Production of products for clinical use and product storage Release testing Shipment to external sites Prep and delivery of products for infusion Post infusion immune monitoring with Flow Cytometry Shared Resource Equipment/Software CliniMACS Cell Separation Device X 2 CliniMACS Prodigy Cell Culture and Separation Device BD Canto II Flow Cytometer Top Count LN2 Controlled Rate Freezers and Storage Tanks Cobe 2991 Cell Washers x 2 Biological Safety Cabinets Inverted and standard Microscopes CO2 Incubators with Hepa Filtration Sterile Connecting Devices and tubing sealers Table Top and Floor Model Centrifuges X 4 | View | No | No |
| Froedtert Hospital | | OFFICE OF CLINICAL RESEARCH & INNOVATIVE CARE COMPLIANCE (OCRICC) More Info | Even with IRB approval, a project requiring use of any FH resource cannot begin activities without FH final Administrative Approval granted though OCRICC. Your project must be reviewed by and receive FH Administrative Approval through the FH Office of Clinical Research & Innovative Care Compliance (OCRICC) if you plan to conduct your research at any Froedtert Health (FH) System entity (Froedtert Hospital, Community Memorial Hospital, St. Joseph West Bend, or any of our clinics), and/or utilize any FH resource for your research. These resources include, but not limited to, the following: Cinical services (i.e., radiology imaging) Surgical/interventional services Staff time Equipment Space (i.e., inpatient, FH clinics, FH ancillary services, etc.) Drugs Devices Lab services (except for services provided by Dynacare that are set up as external clients) Specimens, including “discard” tissue from any FH or OR procedure area, and/or Patient Health Information (PHI) If you are unsure whether the resources involved in your project are FH resources, or if you are unclear exactly what resources you will need for your project, please contact OCRICC prior to your IRB submission. OCRICC recommends that you contact them no later than submission to the IRB. | View | No | No |
| Froedtert Hospital | | REDCap More Info | REDCap is a mature, secure web application for building and managing online surveys and databases. While REDCap can be used to collect virtually any type of data, it is specifically geared to support data capture for research studies. The REDCap Consortium is composed of 1,436 active institutional partners in 90 countries who utilize and support REDCap in various ways. | View | Yes | No |
| Froedtert Hospital | | RESEARCH PARTICIPANT ADVOCATE More Info | The Research Participant Advocate (RPA) is available to assist in protecting the safety and confidentiality of the research participants who volunteer for clinical studies. The RPA is a resource for potential research volunteers and a liaison and consultant to research teams. The RPA can provide education and/or assistance on issues relating to human subject protection including the following: Informed consent forms and processes Data and safety monitoring plans and boards Participant safety Conflicts of interest Regulatory statutes regarding human subjects Adverse events | View | Yes | No |
| Froedtert Hospital | | SLEEP LABORATORY More Info | A Sleep Laboratory, dedicated for clinical investigation, was recently established within the Adult Translational Research Unit (TRU) of the Clinical and Translational Science Institute (CTSI). Because of its portability, Sleep Lab equipment can also be used in any location outside the Adult TRU, including the intensive care unit and hospital wards. This new capability expands the number and types of studies that can be performed. | View | Yes | No |
| Froedtert Hospital | | TRANSLATIONAL CARDIAC AND VASCULAR FUNCTION UNIT More Info | The Translational Cardiac and Vascular Function Unit, situated in the Adult TRU, has been folded into the TRUs for CTSI investigator use. TECHNOLOGY & RESOURCES GE Vivid 7 echocardiograph and 3S probe are available for human cardiac echocardiography Data analyzed using GE Q analysis software (EchoPAC platform) Three separate vascular ultrasound units (GE Logiq 500, Sonosite 180 plus, and a newer all digital Sonosite MicroMaxx unit, each with probes for high resolution vascular or cardiac imaging) are coupled with Brachial Analysis software for quantifying flow-induced vasodilation and with software for calculating intimal medial thickness and available exclusively for research Separate Itamar EndoPat 2000 tonometry unit for non-invasive assessment of endothelial function is dedicated for use by CTSI investigators, a SphygmoCor® Px Pulse Wave Velocity System, and a SphygmoCor® Mx Pulse Wave Velocity System for non-invasive, reproducible measures of arterial stiffness has recently been acquired. Hokanson Digital Venous Plethysmograph. | View | Yes | No |
| Location | Location | Name | Description | Link |
Important Note to Research Teams
Even with IRB approval, a project requiring use of any FH resource cannot begin activities without FH final Administrative Approval granted though OCRICC.
Your project must be reviewed by and receive FH Administrative Approval through the FH Office of Clinical Research & Innovative Care Compliance (OCRICC) if you plan to conduct your research at any Froedtert Health (FH) System entity (Froedtert Hospital, Community Memorial Hospital, St. Joseph West Bend, or any of our clinics), and/or utilize any FH resource for your research. These resources include, but not limited to, the following:
- Cinical services (i.e., radiology imaging)
- Surgical/interventional services
- Staff time
- Equipment
- Space (i.e., inpatient, FH clinics, FH ancillary services, etc.)
- Drugs
- Devices
- Lab services (except for services provided by Dynacare that are set up as external clients)
- Specimens, including “discard” tissue from any FH or OR procedure area, and/or
- Patient Health Information (PHI)
If you are unsure whether the resources involved in your project are FH resources, or if you are unclear exactly what resources you will need for your project, please contact OCRICC prior to your IRB submission.
OCRICC recommends that you contact them no later than submission to the IRB. You can contact them by email: ocricc@froedterthealth.org or their pages on the Froedtert & the Medical College of Wisconsin website.
PARTNERS
