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COVID-19 Research Index

COVID-19 Research Index

The Medical College of Wisconsin (MCW) and CTSI partners are currently engaged in a number of research initiatives and clinical trials related to the COVID-19 pandemic. CTSI and the MCW Office of Research have created the following list of activities to facilitate awareness, collaboration, and team science in southeast Wisconsin for researchers studying the coronavirus.

The Clinical Trials section includes IRB approved studies of investigational treatments for COVID-19 that are currently accepting patients. New studies can be added to this list upon activation. To add a study to this list, please complete the form.

Team-science based, integrated clinical and research ensembles have been created to address the unmet health needs of our patients, our communities, and health systems during the acute and post-COVID-19 periods. These ensembles facilitate and support the nucleation of basic, clinical/translational, and community researchers in the development of COVID-19 projects in five main categories: (1) Clinical Environment, (2) Community Engagement, (3) Epidemiology, (4) Health System Reform, and (5) Treatment and Vaccine.

COVID-19 Clinical Trials

COVID- XPORT-CoV-1001

Summary

This is a randomized phase 2 single-blinded study of low dose oral selinexor versus placebo to evaluate the activity and safety, as well as reduction in mortality in patients with severe COVID-19.

Patient Population: Inpatient

Principal Investigator
Parameswaran Hari, Cancer Center, Medical College of Wisconsin

Coordinator(s) and Contact Information
Jennifer Peterson  /  Email hidden; Javascript is required.

Expanded Access to Convalescent Plasma for the Treatment of Patients with COVID-19

Summary

Responding to the unprecedented challenge of fighting coronavirus disease 2019 (COVID-19), the U.S. Government is supporting a national Expanded Access Program to collect and provide convalescent plasma to patients in need across the country. Plasma from recovered COVID-19 patients contains antibodies that may help fight the disease.

Working collaboratively with industry, academic, and government partners, Mayo Clinic will serve as the lead institution for the program.

Patient Population: Inpatient

Principal Investigator
Mary Beth Graham, Infectious Disease, Froedtert Hospital

Co-Investigators
Full Name Department Institution / Organization
Patrick Gardner Pathology Medical College of Wisconsin

Coordinator(s) and Contact Information
Sonija Parker  /  Email hidden; Javascript is required.

Expanded Access Treatment Protocol: Remdesivir (RDV;GS-5734) for treatment of SARS-CoV2(CoV) infection

Summary

The primary objective of this study is to provide expanded access of remdesivir (RDV) for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV2) infection.

Patient Population: Inpatient

Principal Investigator
Mary Beth Graham, Infectious Disease, Froedtert Hospital

Coordinator(s) and Contact Information
Sonija Parker  /  Email hidden; Javascript is required.

High-Titer Anti-SARS-CoV-2 Plasma study

Summary

An Open label, Phase 2 Study Evaluating the Efficacy and Safety of High-Titer Anti-SARS-CoV-2 plasma in hospitalized patients with COVID-19 infection.

Patient Population: Inpatient

Principal Investigator
Mary Beth Graham, Infectious Disease, Medical College of Wisconsin

Coordinator(s) and Contact Information
Sonija Parker  /  Email hidden; Javascript is required.

COVID-19 Clinical Environment

Health Implications of the Clinical Environment and Personal Protective Equipment

Summary

Investigate the health implications of personal protective equipment and the clinical environment to healthcare workers and patients in order to better inform future responses to strains on the healthcare system.

Project Leader(s)
Full Name Department Institution / Organization
Jax Sanders, PhD Physics Marquette University
Brian Bennett, PhD Physics Marquette University
Collaborator(s)
Full Name Institution / Organization
Muhammad Bilal Abid, MD Medical College of Wisconsin
Joshua Timpe, MD Medical College of Wisconsin
Konstantin Sobolev, PhD University of Wisconsin - Milwaukee
Christopher Stockdale, PhD Marquette University
Shannon H. Baumer-Mouradian, MD Medical College of Wisconsin
Jax Sanders, PhD Marquette University
Brian Bennett, PhD Marquette University
Ashraf El-Meanawy, MD Medical College of Wisconsin
Xiaoli Ma, PhD University of Wisconsin - Milwaukee
Tom Aufderheide, MD Medical College of Wisconsin

Project Manager(s) and Contact Information
Dessie Levy  /  Email hidden; Javascript is required.

Renee McCoy  /  Email hidden; Javascript is required.

Reallocation of Operating Room (OR) resources during COVID-19 and the impact on healthcare systems

Summary

Explore how operating room (OR) resource allocation impacted healthcare institutions during the COVID-19 pandemic of 2020. In preparation for and during the COVID-19 pandemic, many hospitals and health systems cancelled elective surgeries and were not conducting those surgeries for an extended period of time. This change had significant impacts on health systems leading to reallocation of resources (e.g. space, supplies, employees), decreased revenue, employee furloughs, and a backlog of patients that need to be rescheduled once operations resume. The COVID-19 pandemic exposed vulnerabilities in health system decision-making and approaches to resource allocation. Potential Team Products: Grant, Education Materials (i.e. decision-making metric for OR resource allocation, technologies for healthcare training), Process (i.e. organizational decision-making tool).

Project Leader(s)
Full Name Department Institution / Organization
Peter Rossi, MD Vascular Surgery Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Lisa Thiemann PhD, RN Marquette University
Mark Kosfeld, MBA University of Wisconsin - Milwaukee
Brianne Bakken, PharmD, MHA Medical College of Wisconsin

Project Manager(s) and Contact Information
Dian Mitrayani  /  Email hidden; Javascript is required.

What is psychological stress from COVID-19 on healthcare workers?

Summary

Reduce stress on healthcare workers caused by COVID-19. Healthcare workers who worked in the high-risk hospital units during the SARS outbreak were significantly more likely to have high PTSD symptom levels than healthcare workers who were not treating infected patients or patients suspected of infection. Potential Team Products: Grant for virtual app to provide counseling.

Project Leader(s)
Full Name Department Institution / Organization
Kristin Kroll, PhD Pediatrics Medical College of Wisconsin
Terri deRoon Cassini, PhD Surgery Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Alexa Anderson, PhD University of Wisconsin - Milwaukee
Jennifer Apps, PhD Medical College of Wisconsin
Brianne Bakken, PharmD Medical College of Wisconsin
Kevin Bozymski, PharmD Medical College of Wisconsin
Sonal Chandratre, MD Medical College of Wisconsin
Terri deRoon-Cassini, PhD Medical College of Wisconsin
Colleen Galambos, PhD, LCSW University of Wisconsin - Milwaukee
Ahamed Iqbal, PhD Marquette University
Karen Kersting, PhD Medical College of Wisconsin
Sara Kohlbeck Medical College of Wisconsin
Kristin Kroll, PhD Medical College of Wisconsin
Kathryn Lauer, MD Medical College of Wisconsin
Natalie McAndrew, PhD, RN University of Wisconsin - Milwaukee

Project Manager(s) and Contact Information
Angie Holtz  /  Email hidden; Javascript is required.

COVID-19 Community Engagement

Genetic susceptibility to COVID-19 through race, ethnicity, and gender

Summary

Understand COVID-19 genetic susceptibility and increased education among Milwaukee’s most vulnerable populations. Research Project # 1: Will ACE2 assay allow us to calculate the risk of DD-polymorphism? Potential Team Products: Pilot Grant, Assay.

Project Leader(s)
Full Name Department Institution / Organization
Raul Urrutia, MD Surgery Medical College of Wisconsin
Honey Reddi, PhD Pathology Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Donald Basel, MD Medical College of Wisconsin
Nathan Smith, MD Medical College of Wisconsin
Michael Cain, MD Medical College of Wisconsin
Sherry Ann Brown, MD Medical College of Wisconsin
Amy Pan, PhD Medical College of Wisconsin
Rodney Willoughby, MD Medical College of Wisconsin
Mohan Dhariwal, MD Medical College of Wisconsin
Pippa Simpson, PhD Medical College of Wisconsin
Tom Aufderheide, MD Medical College of Wisconsin
Aaron Winn, MD Medical College of Wisconsin
Sanjay Bhandari, MD Medical College of Wisconsin
Paula North, MD, PhD Medical College of Wisconsin
Wael Saber, MD, MS Medical College of Wisconsin
Honey Reddi, PhD Medical College of Wisconsin
Noorie Hyun, PhD Medical College of Wisconsin
David Joyce, MD Medical College of Wisconsin
Gulrayz Ahmed, MD Medical College of Wisconsin
Muhammad Abid, MD Medical College of Wisconsin
Cary Costello, PhD University of Wisconsin - Milwaukee
Won Chul Song, PhD Milwaukee School of Engineering
Judy Kim, MD Medical College of Wisconsin
Sanjay Bhandari, MD Medical College of Wisconsin
Kathleen Muglia, DNP, APRN Marquette University
Assem Mahfoud, PhD Medical College of Wisconsin
Mary Horowitz, MD, MS Medical College of Wisconsin
Amy Prunuske, PhD Medical College of Wisconsin
Kwanza Devlin, MD Medical College of Wisconsin
Nissim Stolberg, DO Medical College of Wisconsin
Allison Kriegel, PhD Medical College of Wisconsin
Chiang-Ching Huang, PhD Medical College of Wisconsin
Serdar Bozdag, PhD Marquette University

Project Manager(s) and Contact Information
David Zimmerman  /  Email hidden; Javascript is required.

Health disparities: Health inequity challenges for African Americans during COVID-19

Summary

Investigate healthcare practices and actions toward African Americans during COVID-19 social distancing. African Americans lead the health disparities (HBP, HD, Diabetes, Obesity) and coronavirus cases (positive and death) in Wisconsin. How has healthcare providers addressed these challenges mental, physically and spiritually?

Collaborator(s)
Full Name Institution / Organization
Abir Bekhet, PhD, RN Marquette University
Kathryn Berlin, DO Medical College of Wisconsin
Laura Brusky, MD Medical College of Wisconsin
Cary Costello, PhD University of Wisconsin - Milwaukee
Jeanne Erickson, PhD, RN, AOCN University of Wisconsin - Milwaukee
Bryan Johnston, MD Medical College of Wisconsin
Meagan Ladell, MD Medical College of Wisconsin
Yura Lee, PhD University of Wisconsin - Milwaukee
Michael Levas, MD Medical College of Wisconsin
David Nelson, PhD Medical College of Wisconsin
Anna Palatnik, MD Medical College of Wisconsin
Katherine Quinn, PhD Medical College of Wisconsin
Alexandra Radowicz Medical College of Wisconsin
Kathryn Rapala, DNP, JD, RN Marquette University
Madeline Winn, PA-C Medical College of Wisconsin
Ke Yan, PhD Medical College of Wisconsin
Staci Young, PhD Medical College of Wisconsin
Jie Yu, PhD University of Wisconsin - Milwaukee

Project Manager(s) and Contact Information
Dessie Levy, PhD, RN  /  Email hidden; Javascript is required.

Substance use changes in drug and alcohol use during COVID-19

Summary

Provide support to substance users (patients) impacted by COVID-19 restrictions (i.e. safe-at-home, homeless, liquor stores are essential, etc.). Individuals may have increased access and use to alcohol, opioids or other substances that they turned to during the social distancing and seclusion of being at home/homelessness. Conduct retrospective chart review of morbidity and mortality in persons with substance use disorders (SUDs) and increases in opioid overdoses. Potential Team Products: Grant for community outreach/service.

Project Leader(s)
Full Name Department Institution / Organization
Julia Dickson-Gomez, PhD Epidemiology Medical College of Wisconsin
Staci A. Young, PhD Family Medicine Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Lisa Berger, PhD University of Wisconsin - Milwaukee
Aaron Winn, PhD Medical College of Wisconsin
Alexa Anderson, PhD University of Wisconsin - Milwaukee
Jennifer Hernandez-Meier, PhD Medical College of Wisconsin
Sanjay Bhandari, MD Medical College of Wisconsin
Jan Fertig, PhD Milwaukee School of Engineering
Staci Young, PhD Medical College of Wisconsin
Constance Kostelac, PhD Medical College of Wisconsin
Amy Zosel, MD Medical College of Wisconsin
Bryan Johnston, MD Medical College of Wisconsin
Jenessa Price, PhD Medical College of Wisconsin

Project Manager(s) and Contact Information
Dessie Levy  /  Email hidden; Javascript is required.

Renee McCoy  /  Email hidden; Javascript is required.

Use of technology to address health disparities related to COVID-19

Summary

Improve the COVID-19-related health outcomes in underrepresented minority/underserved communities via an ‘app’ for hand-held device (i.e., Health Radius smartphone app) with capabilities for symptom tracking, contact tracing, and exposure alerts. Potential Team Products: Handheld device application (app); Grant submission/acquisition; Expansion of CTSI Community Connectome membership/partnership.

Project Leader(s)
Full Name Department Institution / Organization
David L Joyce, MD Surgery Medical College of Wisconsin
Doriel D Ward, PhD, MPH Clinical & Translational Science Institute Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Sherry Ann Brown MD, PhD Medical College of Wisconsin
Orsolya Garrison, DrPH, MPH Medical College of Wisconsin
Laura Brusky, MD Medical College of Wisconsin
Wonchan Choi, PhD University of Wisconsin - Milwaukee
Melanie Gray, PhD, RN Milwaukee Area Technical College
David Joyce, MD Medical College of Wisconsin
Evelyn Chan, MD, MS Medical College of Wisconsin
Yura Lee, PhD University of Wisconsin - Milwaukee
Alexandra Radowicz Medical College of Wisconsin

Project Manager(s) and Contact Information
Dessie Levy, PhD, RN  /  Email hidden; Javascript is required.

Renee McCoy  /  Email hidden; Javascript is required.

COVID-19 Epidemiology

Develop COVID-19 Diagnostic Tools

Summary

Develop tools and techniques to help with battling the COVID-19 pandemic and even consider tools for future pandemics. There is a significant backlog of testing for the COVID-19 virus in the US. Even with individual labs conducting 30,000 tests a day more than 100,000 tests remain untested. Furthermore, time taken with current testing methods is several days. New devices are being built but remain to be validated. One aptamer-based device on market remains unvalidated.

Project Leader(s)
Full Name Department Institution / Organization
Nathan J Schloemer, MD Pediatrics Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Junjie Niu, PhD University of Wisconsin - Milwaukee
Kathryn Berlin, DO Medical College of Wisconsin
Christopher Pawela, PhD Medical College of Wisconsin
Marcia Silva, PhD University of Wisconsin - Milwaukee
Pippa Simpson, PhD Medical College of Wisconsin
Wujie Zhang, PhD Milwaukee School of Engineering
Angela Mathison, PhD Medical College of Wisconsin
James Verbsky, MD, PhD Medical College of Wisconsin
Spencer Huang, PhD University of Wisconsin - Milwaukee
Woo Jin Chang, PhD University of Wisconsin - Milwaukee
Peter LaViolette, PhD Medical College of Wisconsin
Zeyun Yu, PhD University of Wisconsin - Milwaukee
Rodney Willoughby, MD Medical College of Wisconsin
Faisal Shaikh, PhD Milwaukee School of Engineering
Sue Kehl, PhD Medical College of Wisconsin

Project Manager(s) and Contact Information
Ciara Davis  /  Email hidden; Javascript is required.

Develop point of care testing for COVID-19 and other infectious diseases

Summary

This team’s purpose will improve: (1) Diagnosis and Testing; (2) Healthcare System and Operations; (3) All patients, healthcare staff, and healthcare systems will benefit from this research; (4) Service industries and the general public. There is a significant backlog of testing for the COVID-19 virus in the US. Even with individual labs conducting 30,000 tests a day more than 100,000 tests remain untested. Furthermore, time taken with current testing methods is several days. New devices are being built but remain to be validated. One aptamer-based device on market remains unvalidated. Potential Team Products: This team is interested in developing an instant, inexpensive COVID-19 diagnostic testing kit, similar to that of a pregnancy test, with the ability to do at home and with an indicator of change in color.

Project Leader(s)
Full Name Department Institution / Organization
Abhay Singh Chauhan, PhD, MPharm, BPharm Biopharmaceutical Sciences Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Woo Jin Chang, PhD University of Wisconsin - Milwaukee
Andrew Dentino DDS, PhD Marquette University
Peter LaViolette, PhD Medical College of Wisconsin
Todd Rex Miller, PhD University of Wisconsin - Milwaukee
Amy Prunuske, PhD Medical College of Wisconsin
Ahmed Sayed MD, DrPH Medical College of Wisconsin
Faisal Shaikh, PhD Milwaukee School of Engineering
Marcia Silva, PhD University of Wisconsin - Milwaukee

Project Manager(s) and Contact Information
Tanya Aigner  /  Email hidden; Javascript is required.

Impact of COVID-19 pandemic on family caregiving and well-being

Summary

(1) Elucidate the impact of the COVID19 pandemic on caregiver and family well-being; (2) Determine family factors which decrease the risk of poor psychological outcomes. Investigate effects of COVID-19 and social distancing on caregivers and their families. Potential Team Products: Survey on effects of COVID-19 on family life.

Project Leader(s)
Full Name Department Institution / Organization
Jessica Lander Schnell, MD, MPH Pediatrics Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Colleen Galambos, PhD University of Wisconsin - Milwaukee
W. Hobart Davies, PhD University of Wisconsin - Milwaukee
Jeanne Erickson, PhD, RN University of Wisconsin - Milwaukee
Jennifer Apps, PhD Medical College of Wisconsin
Jessica Schnell, MD Medical College of Wisconsin
Laura Brusky, MD Medical College of Wisconsin
Lauren Beverung, PhD Milwaukee School of Engineering
Abiola Keller, PhD, MPH Marquette University
Sadie Larsen, PhD Medical College of Wisconsin
Abir Bekhet, PhD, RN Marquette University

Project Manager(s) and Contact Information
Louann Sullivan  /  Email hidden; Javascript is required.

Study life history of COVID-19 to develop better predicative models of spread, transmissibility and interventions.

Summary

Projects involve tracking COVID-19 using mobile phone location data and artificial intelligence. Reduce COVID-19 transmission through mobile phone alerts that signal movement into geographic regions where the probability of live virus on exposed surfaces is high. Potential Team Products: Mobile App.

Project Leader(s)
Full Name Department Institution / Organization
David L Joyce, MD Surgery Medical College of Wisconsin
Jeffrey Blessing, PhD Rader School of Business Milwaukee School of Engineering
Collaborator(s)
Full Name Institution / Organization
David L Joyce, MD Medical College of Wisconsin
Jeffrey Blessing, PhD Milwaukee School of Engineering
Anna Palatnik, MD Medical College of Wisconsin
Ke Yan, PhD Medical College of Wisconsin
Sherry-Ann Brown, MD, PhD Medical College of Wisconsin
Mark Kosfeld, MBA University of Wisconsin - Milwaukee

Project Manager(s) and Contact Information
Memory Bacon  /  Email hidden; Javascript is required.

Use of biomedical informatics and biologic data for prediction of COVID-19 disease risk

Summary

Leverage existing biomedical data, in conjunction with biological data, to build models of disease risk that can be used to direct future protective actions and risk assessments during the progression of the current pandemic and potential future re-emergences of disease. Potential Team Products: Prospective or retrospective bio-specimen study; multi-hub collaborative project; registry/epidemiologic review of current cases in the Milwaukee area.

Project Leader(s)
Full Name Department Institution / Organization
Ivor Benjamin, MD, FAHA, FAC Cardiovascular Center Medical College of Wisconsin
Carlos Figueroa Castro, MD Medicine Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Anna Palatnik, MD Medical College of Wisconsin
Carlos Figueroa-Castro, MD Medical College of Wisconsin
Ivor Benjamin, MD Medical College of Wisconsin
James Esteban, MD Medical College of Wisconsin
Muhammad Bilal-Abid, MD Medical College of Wisconsin
Sarah Erickson-Bhatt, PhD Marquette University
Sarbagya Pandit, MD Medical College of Wisconsin
Walter Bialkowski, PhD, MS Marquette University
Paula North, MD, PhD Medical College of Wisconsin
Shuping Lai, PhD Medical College of Wisconsin

Project Manager(s) and Contact Information
Kate Woods  /  Email hidden; Javascript is required.

COVID-19 Health System Reform

Community responsive communications to inform at-risk Milwaukee populations about COVID-19 and how to survive, recover and thrive throughout the crisis

Summary

Investigate how the community perceives the information and response to COVID-19? Increase education to the most vulnerable populations susceptible to COVID-19. Understanding the effectiveness of the COVID-19 messages that are being distributed to the community and how they are being perceived. Potential Team Products: Surveys, content development, community education/engagement.

Project Leader(s)
Full Name Department Institution / Organization
Linda Meurer MPH, MD Family and Community Medicine Medical College of Wisconsin
C Greer Jordan, MBA, PhD Office of Diversity and Inclusion Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Gisela G Chelimsky, MD Medical College of Wisconsin
Colleen Galambos, PhD, ACSW, LCSW-C, FGSA University of Wisconsin - Milwaukee
Theresa Jerofke-Owen, PhD, RN Marquette University
John Meurer, MD, MBA Medical College of Wisconsin
Pradeep Jain Ictect, Inc.
Elizabeth Angeli, PhD Marquette University
Jessica Schnell, PhD Medical College of Wisconsin
Nilanjan Loth, PhD Marquette University
Linda Piacentine, PhD, RN, ACNP-BC Marquette University
John Mantsch, PhD Marquette University
James Pokrywczynski, PhD Marquette University
Linda Menck, MA Marquette University
Staci Young, PhD Medical College of Wisconsin
Joseph Byonanebye, PhD Marquette University
Evelyn C.Y. Chan, MD, MS, FACP Medical College of Wisconsin

Project Manager(s) and Contact Information
David Zimmerman  /  Email hidden; Javascript is required.

What changes will COVID-19 bring to clinic workflow in post pandemic environment?

Summary

Research idea involves discharge follow up and the idea of using virtual visits the next day to ensure compliance with discharge instructions but also to improve patient satisfaction scores.

Collaborator(s)
Full Name Institution / Organization
Marjorie Kozlowski, DNP, APRN Marquette University
Teresa Jerofke-Owen, PhD, RN Marquette University
Dennis Shepherd, MD Medical College of Wisconsin
Kwanza Devlin, MD Medical College of Wisconsin
Jeffrey Blessing, PhD Milwaukee School of Engineering
Chiang-Ching Huang, PhD Medical College of Wisconsin

Project Manager(s) and Contact Information
Memory Bacon  /  Email hidden; Javascript is required.

COVID-19 Treatment and Vaccine

Antiviral Therapies

Summary

Develop in vitro, cell culture, or animal model that can be used by multiple investigators to better understand how the virus behaves inside the body and test potential therapies. Potential Team Products: Vaccine and/or antiviral therapy, grant submission.

Collaborator(s)
Full Name Institution / Organization
David Frick, PhD University of Wisconsin - Milwaukee
Weiguo Cui, PhD Versiti
Jieqing Zhu, PhD Versiti
Xuelin Lou, PhD Medical College of Wisconsin
Ashraf El-Meanawy, MD, PhD Medical College of Wisconsin
Kirkwood Pritchard, PhD Medical College of Wisconsin
Neil Hogg, PhD Medical College of Wisconsin

Project Manager(s) and Contact Information
Rebecca Gasper  /  Email hidden; Javascript is required.

Approaches for mitigating the severity and morbidity of COVID-19 disease

Summary

Investigate the biological roles of various proteins in SARS-Cov2 and their roles in supporting treatment & vaccine development. Potential Team Products: Grant, Device (Novel device to isolate and concentrate virus from various samples).

Project Leader(s)
Full Name Department Institution / Organization
Ashraf El-Meanawy, MD, MS, PhD, FASN Medicine Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Brian Smith, PhD Medical College of Wisconsin
David Frick, PhD University of Wisconsin - Milwaukee
Gary C Mouradian Jr, PhD Medical College of Wisconsin
Muhammad Bilal Abid, MD Medical College of Wisconsin
Woo Jin Chang, PhD University of Wisconsin - Milwaukee
Wujie Zhang, PhD Milwaukee School of Engineering
Ashraf El-Meanawy, MD, MS, PhD, FASN Medical College of Wisconsin

Project Manager(s) and Contact Information
Dian Mitrayani  /  Email hidden; Javascript is required.

Collect feasibility data for conduct of future innovative Phase 1/2 clinical trials using existing drugs and biologics

Summary

This team has the following goals: (1) To test N- Acetylcysteine (NAC) in COVID-19 patients. NAC targets cytokine storm, which is instrumental in severe inflammation seen in COVID-19 patients. Potential Team Products: NIH grant, pilot clinical trial. (2) A Phase II/III Randomized Controlled Trial of Salmeterol vs. Placebo for Inpatients with COVID-19 (The Salmeterol Trial) A Phase II/III Randomized Controlled Trial of Salmeterol vs. Placebo for Outpatients with COVID-19 (The Salmeterol Outpatient Trial). Potential Team Products: NIH grant, multicenter clinical trial through either SIREN, MARCH or TIN. Patent application.

Project Leader(s)
Full Name Department Institution / Organization
Tom P Aufderheide, MD Emergency Medicine Medical College of Wisconsin
Jonathan S Marchant, MA, PhD Cell Biology, Neurobiology and Anatomy Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Alison Kriegel, PhD Medical College of Wisconsin
Wujie Zhang, PhD Milwaukee School of Engineering
Kristin Busse, PharmD Medical College of Wisconsin
James Esteban, MD Medical College of Wisconsin
Tom Aufderheide, MD Medical College of Wisconsin
Kirsten Bunnell, PharmD Medical College of Wisconsin
Kia Saeian, MD Medical College of Wisconsin
Sameem Abedin, MD Medical College of Wisconsin
Kathryn Berlin DO Medical College of Wisconsin
Michael Widlansky MD, MPH Medical College of Wisconsin
Ravit Boger, MD Medical College of Wisconsin
Sanjay Bhandari, MD Medical College of Wisconsin
Renren Wen, PhD Versiti
Shawn Jobe, PhD Medical College of Wisconsin
W Hobart Davies, PhD University of Wisconsin - Milwaukee
Jane Njeri Wainaina, MD, FCAP Medical College of Wisconsin
Rodney Willoughby, MD Medical College of Wisconsin
Jonathan Marchant, MA, PhD Medical College of Wisconsin

Project Manager(s) and Contact Information
Dr. Amit Gode  /  Email hidden; Javascript is required.

Develop unique model systems to diagnose, treat or prevent HLB (Heart, Lung & Blood) conditions affected by COVID-19

Summary

Explore current literature to access unmet clinical needs in areas of prevention, diagnosis and treatment of HLB (Heart, Lung & Blood) conditions affected by COVID-19. Potential Team Products: 1. Dr. Marius Schmidt is pursuing special crystallographic methods with CoV-2 enzymes using X-ray Free Electron Lasers. 2. Dr. John Imig is working on a molecule to control cytokine storm, which is undergoing a phase-2 study through his collaborator in CA. 3. Drs. Paula North, Aoy Mitchell and Michael Frank have access to some DNA detection/diagnostic technology developed in their CLIA lab that could be modified for looking at pulmonary endothelial cells for identifying prognostic markers.

Collaborator(s)
Full Name Institution / Organization
Christopher Pawela, PhD Medical College of Wisconsin
Paula North, MD, PhD Medical College of Wisconsin
John Imig, PhD Medical College of Wisconsin
Michael Widlansky MD, MPH Medical College of Wisconsin
Aoy Mitchell, PhD Medical College of Wisconsin
Alison Kriegel, PhD Medical College of Wisconsin

Project Manager(s) and Contact Information
Dr. Shankar Srinivasan  /  Email hidden; Javascript is required.

Epidemiology, genetic hypertension and multiscale computer modeling

Summary

Evaluate demographic and medical history of hospitalized COVID-19 positive patients, identify determinants of disease progression, characterize medication use to identify contraindicated medications, and synthesize findings with lung and bronchus biospecimens to examine potential mechanism in COVID-19 infection. Potential Team Products: Submission to NSF Rapid Funding opportunity, new guidance for clinical practices.

Collaborator(s)
Full Name Institution / Organization
Jennifer McIntosh, DO Medical College of Wisconsin
Curt D Sigmund, PhD Medical College of Wisconsin
Mahsa Dabagh, PhD University of Wisconsin - Milwaukee
Carolyn Oxencis, PharmD, BCPS, BCOP Medical College of Wisconsin
Walter Bialkowski PhD, MS Marquette University

Project Manager(s) and Contact Information
Rebecca Gasper  /  Email hidden; Javascript is required.

Explore technologies that are in final stages of R&D to manage COVID-19

Summary

Develop and market a test to improve patient outcomes. Can a cfDNA test predict de-compensation in COVID patients. Most COVID-19 patients recover with either none or mild symptoms. However, about 15% of cases progress to ARDS with sequelae affecting multiple organ systems. This 15% are difficult to predict and this test will help with building predictor models in identifying possible worse progression of the disease. Potential Team Products: Lab test that predicts acute de-compensation in COVID patients.

Project Leader(s)
Full Name Department Institution / Organization
Aoy Tomita-Mitchell, PhD Surgery Medical College of Wisconsin
Michael E. Mitchell, MD Surgery Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Paula North, PhD Medical College of Wisconsin
El-Sayed Ibrahim, PhD Medical College of Wisconsin
Mary Beth Graham, MD Medical College of Wisconsin
Ranjit Verma, PhD Medical College of Wisconsin
Kristin Busse, PharmD Medical College of Wisconsin
Michael Mitchell, MD Medical College of Wisconsin
John Imig, PhD Medical College of Wisconsin
Ashley Wuerl Medical College of Wisconsin
Aoy Tomita-Mitchell, PhD Medical College of Wisconsin
Jennifer Peterson, PhD Medical College of Wisconsin
Anne Laulederkind, RN Medical College of Wisconsin
Jeanette Graf Medical College of Wisconsin
Marius Schmidt, PhD University of Wisconsin - Milwaukee
Ashraf El-Meanawy, MD, PhD Medical College of Wisconsin
Michael Frank, MD Medical College of Wisconsin
Ramani Ramchandran, PhD Medical College of Wisconsin
Julie Biller, MD Medical College of Wisconsin

Project Manager(s) and Contact Information
Dr. Amit Gode  /  Email hidden; Javascript is required.

Percutaneous RVAD (right ventricular assist device) for COVID-19 ARDS (Acute Respiratory Distress Syndrome)

Summary

Investigate whether the use of RVAD at intubation decreases the chance of multiple system failure for those without co-morbidities. Conventional treatment for those who are diagnosed with ARDS is mechanical ventilation. RVAD support using ProTec Duo is an alternative that allows for less damage to the lungs from mechanical ventilation.

Project Leader(s)
Full Name Department Institution / Organization
David Joyce, MD Surgery Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Gulrayz Ahmed, MD Medical College of Wisconsin
Paula North, MD, PhD Medical College of Wisconsin
Wael Saber, MD, MS Medical College of Wisconsin
Noorie Hyun, PhD Medical College of Wisconsin
Mohan Dhariwal, MD Medical College of Wisconsin
Pippa Simpson, PhD Medical College of Wisconsin
Tom Aufderheide, MD Medical College of Wisconsin
Aaron Winn, MD Medical College of Wisconsin
Sanjay Bhandari, MD Medical College of Wisconsin
Ivor Benjamin, MD Medical College of Wisconsin
Sherry Ann Brown, MD Medical College of Wisconsin
Amy Pan, PhD Medical College of Wisconsin
Emily Neumann Medical College of Wisconsin
Sarah Kastelic Medical College of Wisconsin
Nathan Smith, MD Medical College of Wisconsin
Michael Cain, MD Medical College of Wisconsin
Lucian Durham, MD Medical College of Wisconsin
Adhitya Ramamurthi, MD Medical College of Wisconsin
Carolynn Pinkerton, MD Medical College of Wisconsin
Octavio Falcucci, MD Medical College of Wisconsin
Mark Barash, DO Medical College of Wisconsin

Project Manager(s) and Contact Information
David Zimmerman  /  Email hidden; Javascript is required.

Translational research into the inflammatory response and multi-systemic pathophysiology in COVID-19

Summary

This team’s scope has the potential to improve: (1) Diagnosis/Testing, (2) Treatment, (3) Prevention, (4) Healthcare System/Operations. Investigate the neuroinvasive potential of COV2 via pulmonary nerves and the consequences to the control of breathing. Understand the physiologic mechanism and target therapeutics that will prevent and treat the hematologic and systemic manifestations of COVID-19. Determine the contribution of platelet activating antibodies. Potential Team Products: (1) Diagnostic testing components; (2) Treatments: Currently working with plasma; (3) Clinical Trial Design; (4) Provide leadership in biological correlate group.

Project Leader(s)
Full Name Department Institution / Organization
Shawn Jobe, MD, PhD Cell Biology, Neurobiology and Anatomy Medical College of Wisconsin
Kirkwood A. Pritchard Jr, PhD Pediatric Surgery Medical College of Wisconsin
Collaborator(s)
Full Name Institution / Organization
Lisa M Baumann Kreuziger, MD, MS Medical College of Wisconsin
Ivor Benjamin MD, FAHA, FACC Medical College of Wisconsin
Ashraf El-Meanawy MD, MS, PhD, FASN Medical College of Wisconsin
Hubert V Forster, PhD Medical College of Wisconsin
Matthew R Hodges, PhD Medical College of Wisconsin
El-Sayed H Ibrahim, PhD, MSE, MSc, BSc Medical College of Wisconsin
John Imig, PhD Medical College of Wisconsin
David Joyce, MD Medical College of Wisconsin
Alison Kriegel, PhD Medical College of Wisconsin
Suresh Kumar, PhD Medical College of Wisconsin
Mingyu Liang, PhD Medical College of Wisconsin
Xuelin Lou PhD Medical College of Wisconsin
Jennifer McIntosh, DO Medical College of Wisconsin
Aoy Mitchell, PhD Medical College of Wisconsin
Michael Mitchell, MD Medical College of Wisconsin
Gary Mouradian, PhD Medical College of Wisconsin
Paula North, MD, PhD Medical College of Wisconsin
Jieqing Zhu, PhD Versiti
Peter J Rossi, MD Medical College of Wisconsin
Curt D Sigmund, PhD Medical College of Wisconsin
Pippa Simpson, PhD Medical College of Wisconsin
Renren Wen, PhD Versiti
Michael Widlansky MD, MPH Medical College of Wisconsin

Project Manager(s) and Contact Information
Tanya Aigner  /  Email hidden; Javascript is required.

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PARTNERS

VersitiChildren's Hospital of WisconsinVA Medical CenterMarquette UniversityMSOEUWM