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Adult Echocardiography Core Laboratory

August 30, 2013  |  Froedtert
Clinical & Translational Science Institute of Southeast Wisconsin

CTSI Core / Facility

The Adult Echocardiography Core provides high-quality cardiovascular imaging along with quantitative and qualitative imaging analysis for cardiovascular clinical trials and investigator initiated protocols. The Core faculty and staff offers expertise, materials, consultation, performs scanning and analysis on a fee for service basis.

The Core serves Investigators affiliated with the Medical College of Wisconsin. We provide consultation on image acquisition and analysis based upon American Society of Echocardiography (ASE) recommendations for the performance and evaluation of a comprehensive transthoracic echocardiogram, use of echocardiography in clinical trials and employ the ASE Standards for Echocardiography Core Laboratories.

Successful and timely scanning and data analysis requires a concerted, collaborative effort of the Investigator and the Core staff in all stages of the study. Investigators planning on utilizing Core services are therefore encouraged to contact the staff early in the planning stages of the study.

About the Core

Consultation services are provided by one of two board-certified cardiologists with extensive backgrounds in cardiac imaging and clinical research. As one of the largest medical research facilities in Wisconsin, we are able to offer a wide range of expertise in cardiac and vascular imaging. The Medical Director of the Echo Core Lab, Jennifer Strande, MD, PhD provides consultation with investigators to optimize the acquisition of data and provide qualitative and quantitative results for a clinical trial or research study while maintaining compliance with regulatory guidelines.

Echocardiography is the cornerstone of the cardiovascular structure and hemodynamic assessment. Its highly versatile nature makes it the non-invasive tool of choice. This form of non-invasive assessment is ideal for performing serial evaluations of cardiac function or real-time monitoring during and after pharmacological or therapeutic intervention. Echocardiography has the versatility that allows for rapid and comprehensive evaluation of cardiac structure, myocardial function, valvular hemodynamics and vascular structure. Protocols are adaptable to the needs of the investigator.


Compliance, Confidentiality and Quality Assurance

All Core Lab studies follow the American Society of Echocardiography (ASE) Recommendations for the use of Echocardiography in Clinical Trials (JASE, 2004; 17:1086-1119) and the ASE Standards for Echocardiography Core Laboratories (JASE, 2009; 22:755-765.)

Standard Operating Procedures and protocols are unique to every study. Imaging protocols are developed upon consultation with the Principal Investigator or in accordance with sponsor written protocols.

A dedicated scanning room for all ultrasound studies to ensure subject comfort and privacy is located in the Clinical and Translational Science Institute on the Medical College of Wisconsin/Froedtert Health Campus. In addition, a state-of-the-art Xcelera workstation is used for image analysis. This system allows import of DICOM compatible data and performs advanced imaging analysis such as: 3D, Advanced 3D Quantification, 2D and Doppler Strain and IMT.

To maintain confidentiality, subject records/data are stored in a locked cabinet in the Echo Core Lab office and on Medical College of Wisconsin Corporate password protected computers. Only investigators and study staff identified on an approved Institutional Review Board protocol are authorized access to study specific documents and data.

All ultrasound studies are preliminarily reviewed by a Registered Diagnostic Cardiac Sonographer with the final interpretation made by a board certified Cardiologist to ensure accuracy of the final report. We are able to provide blinded analysis for your study.


Adult TRU (Translational Research Unit) LL Pavillion, Froedtert Hospital


8 am – 4:30 pm, Monday – Friday

Special arrangements for service outside these times can be scheduled.

USRoom Binders


Comprehensive Screening Echocardiogram

Serial Screening Echocardiogram

Limited 2D Echocardiogram for Left Ventricle Function

Saline Contrast Echocardiogram

Trans-pulmonary Contrast Studies for Myocardial Perfusion or Function

Carotid Intima-Media Thickness (CIMT)

Customized Echocardiography

Strain/Strain Rate Analysis of Left Ventricle

Doppler Analysis of Diastolic Function, Transvalvular Velocities and Valve Regurgitation


Click any image below to enlarge.


Philips iE33 cardiovascular ultrasound system from Philips Healthcare
USRoom This system includes an S5-1 sector transducer, an L11-3 linear array transducer and an X3-1 matrix transducer for 3D image acquisition. Features include harmonic imaging, M-mode, tissue velocity imaging, spectral Doppler, color flow Doppler, 4D and ECG gated 3D imaging.

Xcelera Focus Workstation
XceleraThe Xcelera Focus workstation includes offline analysis of IMT, strain, Tissue Motion Quantification (TMQA), and 3D assessment of cardiac structure and function.

GE Vivid 7 cardiovascular ultrasound system from GE Healthcare
V7This system includes an M3S sector transducer. Features include coded harmonic imaging, real-time anatomical M-mode, 2D speckle tracking (strain) imaging, tissue velocity imaging, spectral Doppler, and color flow Doppler.

EchoPAC with Q analysis system
EchopacThe EchoPAC with Q analysis system is available for offline analysis.


Request CTSI Services to establish timeline and to review the experimental design.

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The core is not a business and does not attempt to generate net revenue. The Core’s only mission is to support and enable clinical trials by other Investigators.



Echocardiography protocols are developed in accordance with guidelines and standards published by the American Society of Echocardiography.  Upon consultation with the Core Medical Director imaging parameters are designed.  Studies for clinical trials are performed in accordance with the sponsor supplied protocol with report/data transfer as specified.

View ASE Guidelines and Standards

Contact Us


Leanne Harmann, BA, RDCS, RDMS, RVT (Primary Contact)
Core Technical Director and Sonographer
voice: (414) 805-7205
fax: (414) 955-6203


Jennifer Strande, MD, PhD
Core Medical Director
voice: (414) 456-7568
fax: (414) 456-6515


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