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of Clinical and Translational Research. AIMS & OBJECTIVES Specific Aim 1 – Foster the next generation translational workforce by providing BERD education and training designed to increase quantitative knowledge and skills in using appropriate methodologies and embracing state-of-the-art technologies. OR (Evaluation Metrics Table) Increase quantitative knowledge & skill among CTSI investigators and scholars in SE Wisconsin Objective 1: Create a data science certificate related to translational research Objective 2: Use the mini-grant mechanism as the main BERD consultation vehicle Objective 3: Integrate existing resources to complement BERD services Objective 4: Enhance the visibility of BERD services Specific Aim 2 –...

Biostatistics, Epidemiology and Research Design (BERD) Mini-grants BERD Mini-grants provide limited statistical support to investigators on study design and sample size analysis for up to 6 hours. The types of statistical consultation that mini-grants support include: assistance with data analysis plan sample size calculation consultation for project aims and study design short preliminary data analyses related to study design review of preliminary data analysis and interpretation of findings Statistical Support Statistical support is provided by biostatistics faculty from within: The Division of Biostatistics at Medical College of Wisconsin The Biostatistics Division of the Zilber School of Public Health at University...

applied benefits to at least one of the three BERD components: Biostatistics, Epidemiology, and Research Design. The duration of the Award is 12 months. Under this mechanism, up to 2 awards for meritorious proposals will be selected for up to $25,000 each. KEY DATES Intent to Apply due: October 31, 2023 @ 5:00 p.m. CDT Application Deadline via REDCap: January 8, 2024 @ 5:00 p.m. CDT* Notifications of recommendation for award: April 8, 2024 IRB/IACUC Submission Deadline: April 15, 2024* Mandatory orientation for PIs/mPIs whose project has been recommended for funding: April/May 2024 Pilot-BERD start date: July 1, 2024** Pilot-BERD...

“An introduction to big data mining of electronic health records with Jupyterhub, R, SQL and SAS” Presented by: Kristen Osinski, Senior Enterprise Business Analyst Rodney Sparapani, PhD, Associate Professor of Biostatistics Bradley Taylor, MBA, Chief Research Informatics Officer, CTSI Course Objective: Since the Affordable Care Act mandated meaningful usage of Electronic Health Records (EHR) data systems in 2011, there has been a paradigm shift in clinical/translational research towards studying EHR administrative databanks. The Clinical and Translational Science Institute (CTSI) of Southeast Wisconsin has been at the forefront of this emerging trend. CTSI Biomedical Informatics has painstakingly created the...

A virtual seminar presented by the CTSI’s Biostatistical, Epidemiology Research & Design (BERD): Title Designing observational studies using electronic health record data Date Friday, March 31 via Zoom. 2:00pm to 3:00pm Speaker Ruta Brazauskas, Associate Professor, Division of Biostatistics, Medical College of Wisconsin About the speaker Dr. Brazauskas is an Associate Professor in the Division of Biostatistics at the Medical College of Wisconsin, a biostatistician for the Center for International Blood and Marrow Transplant Research (CIBMTR) and Primary Immune Deficiency Treatment Consortium (PIDTC). She has extensive experience in designing observational research studies and prospective clinical trials and performing statistical analysis...

A virtual seminar presented by the CTSI’s Biostatistical, Epidemiology Research & Design (BERD): Genomics Technologies and Resources for Translational Research Since the completion of human genome project in 2003, genomics has progressively come to play a central role in basic and translational research. Over the last two decades, numerous genomic technologies, bioinformatics and computational tools have been developed to accelerate the discovery of genomic information and its application in all areas of biomedical research as well as clinical and public health practices. In this seminar, genomic core facilities and services that are available through CTSI will be introduced. A survey...

CTSI Academy Spotlight Seminar Series May 26 A free seminar titled, Working with EHR Data: Defining Your Outcomes , will be presented by the CTSI’s Biostatistical, Epidemiology Research & Design (BERD) on Friday, May 26, from 2:00 – 3:00 p.m. via Zoom. The featured speaker is Sergey Tarima, PhD, Associate Professor of Biostatistics, MCW. Electronic health records (EHR) data present many complexities not seen in more traditional chart-review based observational studies. Even when the study cohort has been conceptually defined by inclusion and exclusion criteria, translating a research question into statistical terminology is not a trivial task. Discuss how study...

A virtual seminar presented by the CTSI’s Biostatistical, Epidemiology Research & Design (BERD): Title Working with EHR Data: Defining the Study Cohort Date Friday, April 28 via Zoom. 2:00pm to 3:00pm Speaker Anika Szabo, PhD, Professor of Biostatistics, Medical College of Wisconsin and Director of the Biostatistics Consulting Service About the speaker Dr. Szabo is a Professor of Biostatistics at the Medical College of Wisconsin, and the Director of the Biostatistics Consulting Service. She collaborates with biomedical investigators across the entire spectrum of translational research from analyzing cellular assays, animal experiments, and observational studies in patients to designing prospective clinical...

...Community Engagement Consultation Service; Integrating Special Populations; Clinical Research Data Warehouse, BERD; or the recent CTSI/MSOE Deep Learning Initiative, etc.). Integrated Clinical and Research Ensemble Clusters In general, Ensemble RFAs are open to the formation of Pre-Ensembles addressing any unmet patient medical need. However, in September 2021, the Ensemble Function integrated with the Department of Medicine’s Cardiovascular Academic Initiative to release an RFA for “Focused Ensembles” to stimulate the formation of Pre-Ensembles around cardiology-focused unmet patient medical needs. The approved Ensembles from this RFA are collectively known as an Integrated Clinical and Research Cluster. As shown in the figure, an...

CTSI Academy Spotlight Seminar Series June 30 A free seminar titled, Creating an Analytic Dataset from EHR Data , will be presented by the CTSI’s Biostatistical, Epidemiology Research & Design (BERD) on Friday, June 30, from 2:00 – 3:00 p.m. via Zoom. The featured speaker is Chiang-Ching Huang, PhD, Professor of Biostatistics, UWM. Data from Electronic Health Records (EHRs) are a rich source of patient centered data, including information on the patient’s clinical condition, laboratory results, diagnoses, and treatments. However, access and utilization of EHR data for research presents specific challenges. In this presentation, specific data format obtained from TriNetX...

...to the MCW Clinical Trials Office (CTO), Adult, Pediatric, Community/Mobile, and Zablocki VA/Geriatric Translational Research Units (TRU), REDCap Secure Data Collection & Storage, as well as research support services in Biomedical Informatics, and Biostatistics / Epidemiology Research Design (BERD). Please see our website for resources available to our investigators and applicants. REPORTING As an NIH supported program, the CTSI is required to collect benchmark, annual progress, and long-term outcomes reports of all Pilot awarded projects. Timely progress and reporting of the funded research project is a requirement of the award. The CTSI Traditional Pilot Awards are funded by the Medical...

When: March 25, 2022 @ 2:00 pm – 3:00 pm
Where: Virtual via Zoom

Keynote Speaker Professor Aniko Szabo Division of Biostatistics Institute for Health & Equity The Medical College of WI A virtual seminar, Designing Case-Control Studies, will offer examples and advice on designing retrospective observational studies for the evaluation of risk factors, is scheduled on Friday, March...

...services in Biomedical Informatics, and Biostatistics / Epidemiology Research Design (BERD). Please see our website for resources available to our investigators and applicants. Reporting As an NIH supported program, the CTSI is required to collect benchmark, annual progress, and long-term outcomes reports of all Pilot awarded projects. Timely progress and reporting of the funded research project is a requirement of the award. The CTSI Traditional Pilot Awards are funded by the Medical College of Wisconsin (MCW). All applications and awarded projects must follow respective processes including but not limited to reporting requirements. Funding Acknowledgment Important Reminder – Please acknowledge the...

...resources and holistic support. CTSI has systematized the approach to clinical trials by incorporating Informatics; Biostatistics, Epidemiology and Research Design (BERD); translational research workforce training and education, study management tools/resources and regulatory compliance under one roof. During the past five years, MCW/CTSI CTO has supported about 185 research studies/projects. Translational Research Units (TRU) Since 2015, 151 NIH-funded studies have been supported through TRUs, CTO and BMI services. CTSI Pediatric TRU has averaged 2,030 research visits annually over the last four years and has executed 100 protocols; research topics ranged from observational pathophysiologic studies to phase three trials. The Geriatric/Veteran TRU...

CTSI Mini-Grants CTSI offers mini-grants to offset the cost of strategically targeted, external or jointly sponsored services, events, and courses. Currently Open mini-grant opportunities Biostatistical Consultation Mini-grants BERD Mini-grants provide limited statistical support to investigators on study design and sample size analysis for up to 6 hours. The types of statistical consultation that mini-grants support include assistance with data analysis plan, sample size calculation, consultation for project aims and study design, short preliminary data analyses related to study design, and review of preliminary data analysis and interpretation of findings. Recent mini-grant opportunities (Now closed) Interactive Virtual Workshop aimed at laying...

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...for the 2024 Traditional Pilot Awards. Up to 2 meritorious projects will be awarded at up to $50,000 each for the 2024 Traditional Pilot cycle.Read More 2024 CTSI Pilot Translational & Clinical Studies Program Methodological Innovation Award RFA The CTSI of Southeast WI Pilot Translational and Clinical Studies Program (PTCS) is pleased to announce a new opportunity for a Biostatistics, Epidemiology, and Research Design (BERD) Methodological Innovation Award, and requests applications for funding to support development of methodological research. The purpose of this award is to promote innovative tools and methods to address barriers to translational and clinical research.Read More...

NIH Funding Acknowledgment: Important Reminder – Please acknowledge the NIH when publishing papers, patents, projects, and presentations resulting from the use of CTSI resources by including the NIH Funding Acknowledgement.

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Children's Hospital of WisconsinMarquette UniversityMSOEUWMVersitiVA Medical Center